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A 68930 hydrochloride is a potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 307.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.5 mL||32.49 mL||64.98 mL|
|2.5 mM||1.3 mL||6.5 mL||13 mL|
|5 mM||0.65 mL||3.25 mL||6.5 mL|
|25 mM||0.13 mL||0.65 mL||1.3 mL|
References are publications that support the biological activity of the product.
Deveney and Waddingto (1997) Psychopharmacological distinction between novel full-efficacy "D1-like" DA receptor agonists. Pharmacol.Biochem.Behav. 58 551 PMID: 9300618
Kebabian et al (1990) A68930: a potent and specific agonist for the D-1 DA receptor. Am.J.Hypertens. 3 40S PMID: 2143387
Quaglia et al (1990) (1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J.Med.Chem. 33 2948 PMID: 1977907
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Keywords: A 68930 hydrochloride, A 68930 hydrochloride supplier, Potent, selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, A68930, hydrochloride, and, 1534, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for A 68930 hydrochloride include:
Blasic et al (2012) Phosphorylation of mouse melanopsin by protein kinase A. Sci Rep 7 e45387 PMID: 23049792
Guha et al (2012) Stimulation of the D5 DA receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823 PMID: 22639870
Mizuta et al (2013) The DA D1 receptor is expressed and facilitates relaxation in airway smooth muscle. PLoS One 14 89 PMID: 24004608
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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