A 68930 hydrochloride

Pricing Availability   Qty
Description: Potent and selective D1-like agonist
Chemical Name: cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride
Purity: ≥98% (HPLC)
Citations (3)
Literature (4)

Biological Activity for A 68930 hydrochloride

A 68930 hydrochloride is a potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.

Technical Data for A 68930 hydrochloride

M. Wt 307.78
Formula C16H17NO3.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 130465-39-3
PubChem ID 9904672
Smiles OC1=C(O)C=CC2=C1C[C@@H]([C@]3=CC=CC=C3)O[C@H]2CN.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 68930 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 15.39 50

Preparing Stock Solutions for A 68930 hydrochloride

The following data is based on the product molecular weight 307.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.5 mL 32.49 mL 64.98 mL
2.5 mM 1.3 mL 6.5 mL 13 mL
5 mM 0.65 mL 3.25 mL 6.5 mL
25 mM 0.13 mL 0.65 mL 1.3 mL

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Product Datasheets for A 68930 hydrochloride

Certificate of Analysis / Product Datasheet
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References for A 68930 hydrochloride

References are publications that support the biological activity of the product.

Deveney and Waddingto (1997) Psychopharmacological distinction between novel full-efficacy "D1-like" DA receptor agonists. Pharmacol.Biochem.Behav. 58 551 PMID: 9300618

Kebabian et al (1990) A68930: a potent and specific agonist for the D-1 DA receptor. Am.J.Hypertens. 3 40S PMID: 2143387

Quaglia et al (1990) (1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J.Med.Chem. 33 2948 PMID: 1977907

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3 Citations for A 68930 hydrochloride

Citations are publications that use Tocris products. Selected citations for A 68930 hydrochloride include:

Blasic et al (2012) Phosphorylation of mouse melanopsin by protein kinase A. Sci Rep 7 e45387 PMID: 23049792

Mizuta et al (2013) The DA D1 receptor is expressed and facilitates relaxation in airway smooth muscle. PLoS One 14 89 PMID: 24004608

Guha et al (2012) Stimulation of the D5 DA receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823 PMID: 22639870

Do you know of a great paper that uses A 68930 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.