A 68930 hydrochloride

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Cat.No. 1534 - A 68930 hydrochloride | C16H17NO3.HCl | CAS No. 130465-39-3
Description: Potent, selective D1-like agonist
Chemical Name: cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.

Technical Data

M. Wt 307.78
Formula C16H17NO3.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 130465-39-3
PubChem ID 9904672
InChI Key PQPGUUQPTSMLKU-YYLIZZNMSA-N
Smiles OC1=C(O)C=CC2=C1C[C@@H]([C@]3=CC=CC=C3)O[C@H]2CN.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.39 50

Preparing Stock Solutions

The following data is based on the product molecular weight 307.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.25 mL 32.49 mL
5 mM 0.65 mL 3.25 mL 6.5 mL
10 mM 0.32 mL 1.62 mL 3.25 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Deveney and Waddingto (1997) Psychopharmacological distinction between novel full-efficacy "D1-like" dopamine receptor agonists. Pharmacol.Biochem.Behav. 58 551 PMID: 9300618

Kebabian et al (1990) A68930: a potent and specific agonist for the D-1 dopamine receptor. Am.J.Hypertens. 3 40S PMID: 2143387

Quaglia et al (1990) (1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J.Med.Chem. 33 2948 PMID: 1977907


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View all D1 and D5 Receptor Agonists

Keywords: A 68930 hydrochloride, supplier, Potent, selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, A68930, hydrochloride, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience

3 Citations for A 68930 hydrochloride

Citations are publications that use Tocris products. Selected citations for A 68930 hydrochloride include:

Mizuta et al (2013) The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. PLoS One 14 89 PMID: 24004608

Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823 PMID: 22639870

Blasic et al (2012) Phosphorylation of mouse melanopsin by protein kinase A. Sci Rep 7 e45387 PMID: 23049792


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