Dihydrexidine hydrochloride

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Cat.No. 0884 - Dihydrexidine hydrochloride | C17H17NO2.HCl | CAS No. 158704-02-0
Description: Selective D1-like agonist
Chemical Name: (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews (1)
Literature (7)

Biological Activity

A potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.

Licensing Information

Sold under license, US Patent 5,047,536

Technical Data

M. Wt 303.79
Formula C17H17NO2.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 158704-02-0
PubChem ID 11403931
InChI Key IJYUPBNUPIRQEP-SATBOSKTSA-N
Smiles OC1=C(O)C=C(CC[C@]3([H])[C@@]([H])2C4=C(C=CC=C4)CN3)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.04 10
DMSO 15.19 50

Preparing Stock Solutions

The following data is based on the product molecular weight 303.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.58 mL 32.92 mL 65.83 mL
2.5 mM 1.32 mL 6.58 mL 13.17 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Brewster et al (1990) Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective DA D1 full agonist. J.Med.Chem. 33 1756 PMID: 1971308

Kholi et al (1993) Dihydrexidine: a new potent peripheral DA D1 receptor agonist. Eur.J.Pharmacol. 235 31 PMID: 8100195

Lovenberg et al (1989) Dihydrexidine, a novel selective high potency, full DA D-1 receptor agonist. Eur.J.Pharmacol. 166 111 PMID: 2572425

Taylor et al (1991) Dihydrexidine, a full DA D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 199 389 PMID: 1680717


If you know of a relevant reference for Dihydrexidine hydrochloride, please let us know.

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Keywords: Dihydrexidine hydrochloride, Dihydrexidine hydrochloride supplier, Selective, D1-like, agonists, Dopamine, Receptors, D5, dopaminergic, D1, and, 0884, Tocris Bioscience

4 Citations for Dihydrexidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dihydrexidine hydrochloride include:

Parker and Kooi (2014) Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. J Neurosci 453 42525 PMID: 24583243

Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Anal Biochem 7 624 PMID: 21785426

Smith et al (2005) DArgic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45 765 PMID: 15748851

Gorelova et al (2002) Mechanisms of DA activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex. J Neurophysiol 88 3150 PMID: 12466437


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Reviews for Dihydrexidine hydrochloride

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Dose Response of Tango D1-bla Dopamine Receptor Signaling.
By Anonymous on 08/20/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Tango D1-bla U20S

I used this as our positive control when testing dose responses following treatment with our Tango D1-bla U20S cells to measure dopamine receptor 1 activity following treatment with Dihydrexidine.


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