Dihydrexidine hydrochloride

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Cat.No. 0884 - Dihydrexidine hydrochloride | C17H17NO2.HCl | CAS No. 158704-02-0
Description: Selective D1-like agonist
Chemical Name: (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

A potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.

Licensing Information

Sold under license, US Patent 5,047,536

Technical Data

M. Wt 303.79
Formula C17H17NO2.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 158704-02-0
PubChem ID 11403931
InChI Key IJYUPBNUPIRQEP-SATBOSKTSA-N
Smiles OC1=C(O)C=C(CC[C@]3([H])[C@@]([H])2C4=C(C=CC=C4)CN3)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.19 50
water 3.04 10

Preparing Stock Solutions

The following data is based on the product molecular weight 303.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.92 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Brewster et al (1990) Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. J.Med.Chem. 33 1756 PMID: 1971308

Kholi et al (1993) Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. Eur.J.Pharmacol. 235 31 PMID: 8100195

Lovenberg et al (1989) Dihydrexidine, a novel selective high potency, full dopamine D-1 receptor agonist. Eur.J.Pharmacol. 166 111 PMID: 2572425

Taylor et al (1991) Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 199 389 PMID: 1680717


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Keywords: Dihydrexidine hydrochloride, supplier, Selective, D1-like, agonists, Dopamine, Receptors, D5, dopaminergic, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience

3 Citations for Dihydrexidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dihydrexidine hydrochloride include:

Parker and Kooi (2014) Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. J Neurosci 453 42525 PMID: 24583243

Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Anal Biochem 7 624 PMID: 21785426

Smith et al (2005) Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45 765 PMID: 15748851


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