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Biological Activity for Dihydrexidine hydrochloride
Dihydrexidine hydrochloride is an a potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.
Sold under license, US Patent 5,047,536
Technical Data for Dihydrexidine hydrochloride
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dihydrexidine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Dihydrexidine hydrochloride
The following data is based on the product molecular weight 303.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.58 mL||32.92 mL||65.83 mL|
|2.5 mM||1.32 mL||6.58 mL||13.17 mL|
|5 mM||0.66 mL||3.29 mL||6.58 mL|
|25 mM||0.13 mL||0.66 mL||1.32 mL|
Product Datasheets for Dihydrexidine hydrochloride
References for Dihydrexidine hydrochloride
References are publications that support the biological activity of the product.
Brewster et al (1990) Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective DA D1 full agonist. J.Med.Chem. 33 1756 PMID: 1971308
Kholi et al (1993) Dihydrexidine: a new potent peripheral DA D1 receptor agonist. Eur.J.Pharmacol. 235 31 PMID: 8100195
Lovenberg et al (1989) Dihydrexidine, a novel selective high potency, full DA D-1 receptor agonist. Eur.J.Pharmacol. 166 111 PMID: 2572425
Taylor et al (1991) Dihydrexidine, a full DA D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 199 389 PMID: 1680717
If you know of a relevant reference for Dihydrexidine hydrochloride, please let us know.
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Keywords: Dihydrexidine hydrochloride, Dihydrexidine hydrochloride supplier, Selective, D1-like, agonists, Dopamine, Receptors, D5, dopaminergic, D1, and, 0884, Tocris Bioscience
4 Citations for Dihydrexidine hydrochloride
Citations are publications that use Tocris products. Selected citations for Dihydrexidine hydrochloride include:
Smith et al (2005) DArgic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45 765 PMID: 15748851
Gorelova et al (2002) Mechanisms of DA activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex. J Neurophysiol 88 3150 PMID: 12466437
Parker and Kooi (2014) Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. J Neurosci 453 42525 PMID: 24583243
Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Anal Biochem 7 624 PMID: 21785426
Do you know of a great paper that uses Dihydrexidine hydrochloride from Tocris? Please let us know.
Reviews for Dihydrexidine hydrochloride
Average Rating: 5 (Based on 1 Review.)
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I used this as our positive control when testing dose responses following treatment with our Tango D1-bla U20S cells to measure dopamine receptor 1 activity following treatment with Dihydrexidine.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.