Selective D1-like dopamine receptor partial agonist (EC50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).
Sold for research purposes under agreement from GlaxoSmithKline
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 342.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.92 mL||14.61 mL||29.22 mL|
|5 mM||0.58 mL||2.92 mL||5.84 mL|
|10 mM||0.29 mL||1.46 mL||2.92 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hahn et al (1982) Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist. J.Pharmacol.Exp.Ther. 223 305 PMID: 6127401
Nichols et al (1990) The pharmacology of fenoldopam. Am.J.Hypertens. 3 116S PMID: 1974439
Sibley et al (1982) Interactions of novel dopaminergic ligands with D-1 and D-2 dopamine receptors. Life Sci. 31 637 PMID: 6127585
If you know of a relevant reference for Fenoldopam hydrochloride, please let us know.
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Keywords: Fenoldopam hydrochloride, supplier, Selective, D1-like, partial, agonists, Dopamine, Receptors, D5, dopaminergic, SKF82526, GlaxoSmithKline, GSK, SKF, 82526, D1, and, D5, Receptors, Tocris Bioscience
1 Citation for Fenoldopam hydrochloride
Citations are publications that use Tocris products. Selected citations for Fenoldopam hydrochloride include:
Chen et al (2013) Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis. Hypertension 62 927 PMID: 24019399
Do you know of a great paper that uses Fenoldopam hydrochloride from Tocris? If so please let us know.
Literature in this Area
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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