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Biological Activity for Fenoldopam hydrochloride
Fenoldopam hydrochloride is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for Fenoldopam hydrochloride
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fenoldopam hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Fenoldopam hydrochloride
The following data is based on the product molecular weight 342.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||29.22 mL||146.1 mL||292.21 mL|
|0.5 mM||5.84 mL||29.22 mL||58.44 mL|
|1 mM||2.92 mL||14.61 mL||29.22 mL|
|5 mM||0.58 mL||2.92 mL||5.84 mL|
Product Datasheets for Fenoldopam hydrochloride
References for Fenoldopam hydrochloride
References are publications that support the biological activity of the product.
Hahn et al (1982) Characterization of the peripheral and central effects of SK&F 82526, a novel DA receptor agonist. J.Pharmacol.Exp.Ther. 223 305 PMID: 6127401
Nichols et al (1990) The pharmacology of fenol. Am.J.Hypertens. 3 116S PMID: 1974439
Sibley et al (1982) Interactions of novel DArgic ligands with D-1 and D-2 DA receptors. Life Sci. 31 637 PMID: 6127585
If you know of a relevant reference for Fenoldopam hydrochloride, please let us know.
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1 Citation for Fenoldopam hydrochloride
Citations are publications that use Tocris products. Selected citations for Fenoldopam hydrochloride include:
Chen et al (2013) Gastrin and D1 DA receptor interact to induce natriuresis and diuresis. Hypertension 62 927 PMID: 24019399
Do you know of a great paper that uses Fenoldopam hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.