Endogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis. Caged dopamine is also available (Cat. No 3992).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 189.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.27 mL||26.37 mL||52.73 mL|
|5 mM||1.05 mL||5.27 mL||10.55 mL|
|10 mM||0.53 mL||2.64 mL||5.27 mL|
|50 mM||0.11 mL||0.53 mL||1.05 mL|
References are publications that support the products' biological activity.
Rivonello et al (2007) Novel insights into dopamine receptor pharmacology. Eur.J.Endocrinol. 156 S13 PMID: 17413183
Cools (2008) Role of dopamine in the motivational and cognitive control of behavior. Neuroscientist 14 381 PMID: 18660464
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Keywords: Dopamine hydrochloride, supplier, Endogenous, agonists, dopamine, D1, receptors, Dopamine, D2, D3, Non-Selective, Receptors, D5, dopaminergic, TAAR1, D1, and, D5, Receptors, Non-selective, Dopamine, Trace, Amine, 1, Receptor, D1, and, D5, Receptors, Tocris Bioscience
8 Citations for Dopamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Dopamine hydrochloride include:
Zheng et al (2014) Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Physiol Res 306 R138 PMID: 24305061
Zhang et al (2013) Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8 PMID: 23415661
KuÄka et al (2012) Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs. World J Gastroenterol 61 267 PMID: 22480423
Guo (2017) Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. 16 1323 PMID: 28975698
Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by dopamine. Elife 4 PMID: 26516682
Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192 PMID: 26074768
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
O'Keeffe et al (2009) Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A 106 8754 PMID: 19433789
Do you know of a great paper that uses Dopamine hydrochloride from Tocris? If so please let us know.
Dopamine hydrochloride Reviews
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