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Submit ReviewDopamine hydrochloride
Description: Endogenous agonist at dopamine D1-5 receptors
Chemical Name: 3,4-Dihydroxyphenethylamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Dopamine hydrochloride
Dopamine hydrochloride is an endogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis.
Technical Data for Dopamine hydrochloride
| M. Wt | 189.64 |
| Formula | C8H11NO2.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 62-31-7 |
| PubChem ID | 65340 |
| InChI Key | CTENFNNZBMHDDG-UHFFFAOYSA-N |
| Smiles | NCCC1=CC(O)=C(O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dopamine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.96 | 100 | |
| DMSO | 18.96 | 100 |
Preparing Stock Solutions for Dopamine hydrochloride
The following data is based on the product molecular weight 189.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.27 mL | 26.37 mL | 52.73 mL |
| 5 mM | 1.05 mL | 5.27 mL | 10.55 mL |
| 10 mM | 0.53 mL | 2.64 mL | 5.27 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.05 mL |
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Product Datasheets for Dopamine hydrochloride
References for Dopamine hydrochloride
References are publications that support the biological activity of the product.
Rivonello et al (2007) Novel insights into DA receptor pharmacology. Eur.J.Endocrinol. 156 S13 PMID: 17413183
Cools (2008) Role of DA in the motivational and cognitive control of behavior. Neuroscientist 14 381 PMID: 18660464
Fitzgerald and Dinan (2008) Prolactin and DA: what is the connection? A review article. J.Psychopharmacol. 22 S12
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8 Citations for Dopamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Dopamine hydrochloride include:
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by DA. Elife 4 PMID: 26516682
Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768
Zheng et al (2014) Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Physiol Res 306 R138 PMID: 24305061
Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. 16 1323 PMID: 28975698
KuÄka et al (2012) Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs. World J Gastroenterol 61 267 PMID: 22480423
Zhang et al (2013) Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8 PMID: 23415661
O'Keeffe et al (2009) DA-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A 106 8754 PMID: 19433789
Do you know of a great paper that uses Dopamine hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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