Dopamine hydrochloride

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Cat.No. 3548 - Dopamine hydrochloride | C8H11NO2.HCl | CAS No. 62-31-7
Description: Endogenous agonist at dopamine D1-5 receptors
Chemical Name: 3,4-Dihydroxyphenethylamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Literature

Biological Activity

Endogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis. Caged dopamine is also available (Cat. No 3992).

Technical Data

M. Wt 189.64
Formula C8H11NO2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 62-31-7
PubChem ID 65340
InChI Key CTENFNNZBMHDDG-UHFFFAOYSA-N
Smiles NCCC1=CC(O)=C(O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.96 100
water 18.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 189.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.27 mL 26.37 mL 52.73 mL
5 mM 1.05 mL 5.27 mL 10.55 mL
10 mM 0.53 mL 2.64 mL 5.27 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rivonello et al (2007) Novel insights into dopamine receptor pharmacology. Eur.J.Endocrinol. 156 S13 PMID: 17413183

Cools (2008) Role of dopamine in the motivational and cognitive control of behavior. Neuroscientist 14 381 PMID: 18660464

Fitzgerald and Dinan (2008) Prolactin and dopamine: what is the connection? A review article. J.Psychopharmacol. 22 S12 PMID:


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View Related Products by Product Action

View all D1 and D5 Receptor Agonists

Keywords: Dopamine hydrochloride, supplier, Endogenous, agonists, dopamine, D1, receptors, Dopamine, D2, D3, Non-Selective, Receptors, D5, dopaminergic, TAAR1, D1, and, D5, Receptors, Tocris Bioscience

7 Citations for Dopamine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dopamine hydrochloride include:

Kučka et al (2012) Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs. World J Gastroenterol 61 267 PMID: 22480423

O'Keeffe et al (2009) Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A 106 8754 PMID: 19433789

Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by dopamine. Elife 4 PMID: 26516682

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192 PMID: 26074768

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Zheng et al (2014) Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Physiol Res 306 R138 PMID: 24305061

Zhang et al (2013) Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8 PMID: 23415661


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Pathways for Dopamine hydrochloride

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