SKF 38393 hydrobromide

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Cat.No. 0922 - SKF 38393 hydrobromide | C16H17NO2.HBr | CAS No. 20012-10-6
Description: Selective D1-like agonist
Chemical Name: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (18)
Reviews
Literature (7)

Biological Activity

Prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).

Technical Data

M. Wt 336.23
Formula C16H17NO2.HBr
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 20012-10-6
PubChem ID 12928470
InChI Key INNWVRBZMBCEJI-UHFFFAOYSA-N
Smiles Br.OC1=CC2=C(C=C1O)C(CNCC2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.41 25 with gentle warming
DMSO 33.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 336.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.87 mL 29.74 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Geter-Douglass et al (1997) Characterization of unconditioned behavioral effects of DA D3/D2 receptor agonists. J.Pharmacol.Exp.Ther. 283 7 PMID: 9336302

Habuchi et al (1997) DA stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393. Br.J.Pharmacol. 122 1669 PMID: 9422813

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Sibley et al (1982) Interactions of novel DArgic ligands with D1 and D2 DA receptors. Life Sci. 31 637 PMID: 6127585


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Keywords: SKF 38393 hydrobromide, SKF 38393 hydrobromide supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF38393, hydrobromide, and, 0922, Tocris Bioscience

18 Citations for SKF 38393 hydrobromide

Citations are publications that use Tocris products. Selected citations for SKF 38393 hydrobromide include:

Hook et al (2012) DArgic modulation of ganglion-cell photoreceptors in rat. Eneuro 35 507 PMID: 22304466

Prado et al (2012) Stimulation of DA receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Biol Chem 188 3062 PMID: 22379034

Toro et al (2015) DA Modulates the Activity of Sensory Hair Cells. J Neurosci 35 16494 PMID: 26674873

Marcellino et al (2008) Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Front Neurosci 283 26016 PMID: 18644790

Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768

Stramiello (2008) D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology 55 871 PMID: 18644393

Herwerth et al (2012) D4 DA receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cereb Cortex 22 1786 PMID: 21955919

Moreno et al (2014) Cocaine disrupts histamine H3 receptor modulation of DA D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci 34 3545 PMID: 24599455

Jia et al (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci 16 1627 PMID: 24121738

Murugan et al (2013) Diminished FoxP2 levels affect DArgic modulation of corticostriatal signaling important to song variability. Neuron 80 1464 PMID: 24268418

Cilz et al (2014) DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels. Cereb Cortex 24 3195 PMID: 23843440

Burgess et al (2010) DArgic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851

Grochowska et al (2017) Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Rep 18 962 PMID: 28420656

Zhang et al (2018) DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci 59 4441 PMID: 30193315

Zike (2017) OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior. Proc Natl Acad Sci USA 114 5719 PMID: 28507136

Mi (2017) Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT 1A Receptor. Plos One 12 e0168964 PMID: 28085967

Xing et al (2015) DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Eur J Neurosci 9 310 PMID: 26388722

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Immunol 2 PMID: 26465004


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