SKF 38393 hydrobromide

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Cat.No. 0922 - SKF 38393 hydrobromide | C16H17NO2.HBr | CAS No. 20012-10-6
Description: Selective D1-like agonist
Chemical Name: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations (12)
Literature

Biological Activity

Prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).

Technical Data

M. Wt 336.23
Formula C16H17NO2.HBr
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 20012-10-6
PubChem ID 12928470
InChI Key INNWVRBZMBCEJI-UHFFFAOYSA-N
Smiles Br.OC1=CC2=C(C=C1O)C(CNCC2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.62 100
ethanol 8.41 25mM with gentle warming
water 8.41 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 336.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.87 mL 29.74 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Geter-Douglass et al (1997) Characterization of unconditioned behavioral effects of dopamine D3/D2 receptor agonists. J.Pharmacol.Exp.Ther. 283 7 PMID: 9336302

Habuchi et al (1997) Dopamine stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393. Br.J.Pharmacol. 122 1669 PMID: 9422813

Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991

Sibley et al (1982) Interactions of novel dopaminergic ligands with D1 and D2 dopamine receptors. Life Sci. 31 637 PMID: 6127585


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Keywords: Selective D1-like agonists Dopamine D1 Receptors D5 dopaminergic SKF38393 hydrobromide D1 and D5 Receptors

12 Citations for SKF 38393 hydrobromide

Citations are publications that use Tocris products. Selected citations for SKF 38393 hydrobromide include:

Zike (2017) OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior. Proc Natl Acad Sci USA 114 5719 PMID: 28507136

Mi (2017) Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT 1A Receptor. Plos One 12 e0168964 PMID: 28085967

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192 PMID: 26074768

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Immunol 2 PMID: 26465004

Xing et al (2015) Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Eur J Neurosci 9 310 PMID: 26388722

Moreno et al (2014) Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci 34 3545 PMID: 24599455

Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627 PMID: 24121738

Murugan et al (2013) Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability. Neuron 80 1464 PMID: 24268418

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. Eneuro 35 507 PMID: 22304466

Prado et al (2012) Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Biol Chem 188 3062 PMID: 22379034

Burgess et al (2010) Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851

Marcellino et al (2008) Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Front Neurosci 283 26016 PMID: 18644790


Do you know of a great paper that uses SKF 38393 hydrobromide from Tocris? If so please let us know.

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