A 77636 hydrochloride

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Cat.No. 1701 - A 77636 hydrochloride | C20H27NO3.HCl | CAS No. 145307-34-2
Description: Potent, selective D1-like agonist. Orally active
Chemical Name: (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.

Technical Data

M. Wt 365.9
Formula C20H27NO3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 145307-34-2
PubChem ID 9811493
InChI Key RSJAXPUYVJKAAA-JPGJPTAESA-N
Smiles NC[C@@H]2O[C@H]([C@]35CC(CC(C5)C4)CC4C3)CC1=C(O)C(O)=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.59 100
ethanol 36.59 100
water 36.59 100

Preparing Stock Solutions

The following data is based on the product molecular weight 365.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.66 mL 27.33 mL
5 mM 0.55 mL 2.73 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Acquas et al (1994) The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat. Eur.J.Pharmacol. 260 85 PMID: 7957630

Kebabian et al (1992) A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur.J.Pharmacol. 229 203 PMID: 1362704

Lewis et al (1998) Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J.Pharmacol.Exp.Ther. 286 345 PMID: 9655879


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Keywords: Potent selective D1-like agonists Orally active Dopamine D1 Receptors D5 dopaminergic A77636 hydrochloride D1 and D5 Receptors

1 Citation for A 77636 hydrochloride

Citations are publications that use Tocris products. Selected citations for A 77636 hydrochloride include:

Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823 PMID: 22639870


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