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SKF 83566 hydrobromide is a potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.
SKF 83566 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||2.07||5 with gentle warming|
The following data is based on the product molecular weight 413.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.42 mL||12.1 mL||24.2 mL|
|5 mM||0.48 mL||2.42 mL||4.84 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Fritts et al (1998) Locomotor stereotypy produced by dexbenzetimide and scopol. is reduced by SKF 83566, not sulpiride. Pharmacol.Biochem.Behav. 60 639 PMID: 9678647
Meyer et al (1993) Effects of DA D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats. Pharmacol.Biochem.Behav. 44 429 PMID: 8446676
Ohlstein and Berkowitz (1985) SCH 23390 and SK&F 83566 are antagonists at vascular DA and serotonin receptors. Eur.J.Pharmacol. 108 205 PMID: 3884345
Conley et al (2013) Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J.Pharmacol.Exp.Ther. 347 276 PMID: 24008337
If you know of a relevant reference for SKF 83566 hydrobromide, please let us know.
Keywords: SKF 83566 hydrobromide, SKF 83566 hydrobromide supplier, Potent, selective, D1-like, antagonists, Dopamine, Receptors, D5, dopaminergic, SKF83566, hydrobromide, D1, and, Adenylyl, Cyclase, 1586, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SKF 83566 hydrobromide include:
Liu et al (2008) Increased DA level enhances male-male courtship in Drosophila. World J Gastroenterol 28 5539 PMID: 18495888
Xing et al (2015) DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Hum Mol Genet 9 310 PMID: 26388722
Cassar et al (2015) A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila. Learn Mem 24 197 PMID: 25158689
Savalli et al (2015) Regionally selective requirement for D1/D5 DArgic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory. J Neurosci 22 69 PMID: 25593292
Huang et al (2014) D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus. Learn Mem 21 153 PMID: 24549570
Billes et al (2012) Leptin reduces food intake via a DA D2 receptor-dependent mechanism. Mol Metab 1 86 PMID: 24024122
Stramiello (2008) D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology 55 871 PMID: 18644393
Belinsky et al (2013) DA receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev 22 1522 PMID: 23286225
Li et al (2017) DA-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons. J Neurochem 140 550 PMID: 27925199
Leng et al (2017) Activation of DRD5 inhibits tumor growth by autophagic cell death. Autophagy 13 1404 PMID: 28613975
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