SCH 39166 hydrobromide

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Cat.No. 2299 - SCH 39166 hydrobromide | C19H20ClNO.HBr | CAS No. 1227675-51-5
Description: High affinity D1-like antagonist
Alternative Names: Ecopipam hydrobromide
Chemical Name: (6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

High affinity dopamine D1/D5 receptor antagonist; displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively.

Technical Data

M. Wt 394.73
Formula C19H20ClNO.HBr
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1227675-51-5
PubChem ID 16759171
InChI Key GAUWIDFICGEZKR-JUOYHRLASA-N
Smiles Br.CN1CCC2=C(C=C(O)C(Cl)=C2)[C@@H]2[C@@H]1CCC1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.33 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Wu et al (2005) Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. J.Med.Chem. 48 680 PMID: 15689153

Terry and Katz (1994) A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393. Psychopharmacology 113 328 PMID: 7862841

McQuade et al (1991) In vivo binding of SCH 39166: a D-1 selective antagonist. J.Pharmacol.Exp.Ther. 257 42 PMID: 1826927


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Keywords: SCH 39166 hydrobromide, SCH 39166 hydrobromide supplier, High, affinity, D1/D5, receptor, antagonists, Dopamine, Receptors, dopaminergic, SCH39166, hydrobromide, Ecopipam, D1, and, D5, 2299, Tocris Bioscience

6 Citations for SCH 39166 hydrobromide

Citations are publications that use Tocris products. Selected citations for SCH 39166 hydrobromide include:

Zheng et al (2014) Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Nat Commun 306 R138 PMID: 24305061

Mizuta et al (2013) The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. Am J Physiol Regul Integr Comp Physiol 14 89 PMID: 24004608

Sink et al (2008) Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior. Psychopharmacology (Berl) 196 565 PMID: 18004546

Lim et al (2014) A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats. J Neurosci 34 9779 PMID: 25031415

Fleischmann et al (2014) RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes. Mol Cancer 13 27 PMID: 24517546

Nunes et al (2010) Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism. Neuroscience 170 268 PMID: 20600675


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