SKF 81297 hydrobromide

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Cat.No. 1447 - SKF 81297 hydrobromide | C16H16ClNO2.HBr | CAS No. 67287-39-2
Description: D1 agonist
Chemical Name: (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (21)
Reviews (1)
Literature

Biological Activity

Dopamine D1-like receptor agonist. Centrally active following systemic administration in vivo.

Compound Libraries

SKF 81297 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 370.67
Formula C16H16ClNO2.HBr
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 67287-39-2
PubChem ID 11957706
InChI Key RMIJGBMRNYUZRG-UHFFFAOYSA-N
Smiles Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.07 100
water 3.71 10

Preparing Stock Solutions

The following data is based on the product molecular weight 370.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.49 mL 26.98 mL
5 mM 0.54 mL 2.7 mL 5.4 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Arnt et al (1988) Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. Pharmacol.Toxicol. 62 121 PMID: 3259694

Peacock et al (1990) The effects of dopamine D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur.J.Pharmacol. 186 49 PMID: 1980891

Reavill et al (1993) Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297. Behav.Pharmacol. 4 135 PMID: 11224180


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Keywords: SKF 81297 hydrobromide, SKF 81297 hydrobromide supplier, D1, agonists, Dopamine, Receptors, D5, dopaminergic, SKF81297, hydrobromide, and, 1447, Tocris Bioscience

21 Citations for SKF 81297 hydrobromide

Citations are publications that use Tocris products. Selected citations for SKF 81297 hydrobromide include:

Saika (2018) Chemokine CXCL1 is responsible for cocaine-induced reward in mice. NeurosciPharm Reports 38 145 PMID: 30175527

Li et al (2011) Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation. J Neurochem 118 237 PMID: 21564097

Meunier et al (2015) Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex. PLoS One 10 e0120286 PMID: 25775449

Guo (2017) Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell 16 1323 PMID: 28975698

Parnaudeau et al (2014) Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine. Front Behav Neurosci 8 35 PMID: 24574986

Marley et al (2013) GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. Psychopharmacology (Berl) 8 e70857 PMID: 23936473

Towers and Hestrin (2008) D1-like dopamine receptor activation modulates GABAergic inhibition but not electrical coupling between neocortical fast-spiking interneurons. J Neurosci 28 2633 PMID: 18322106

Stramiello (2008) D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology 55 871 PMID: 18644393

Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Neurosci 7 624 PMID: 21785426

Floresco and Tse (2007) Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. J Neurosci 27 2045 PMID: 17314300

Pezze et al (2015) Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Mol Med Rep 232 2669 PMID: 25820982

Deng et al (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. PLoS One 13 1128 PMID: 20711186

Beckley et al (2016) The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci 36 701 PMID: 26791202

Cilz et al (2014) Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels. Cereb Cortex 24 3195 PMID: 23843440

Södersten et al (2014) Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS Genet 10 e1004574 PMID: 25254549

Spulber et al (2014) PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae. PLoS One 9 e94227 PMID: 24740186

Chen et al (2014) Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons. Alcohol Clin Exp Res 38 777 PMID: 24236888

Olianas et al (2012) Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex. Neurosignals 21 61 PMID: 22456324

Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823 PMID: 22639870

Hodas et al (2012) Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT). Proteomics 12 2464 PMID: 22744909

Krishnan et al (2011) Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. PLoS One 6 e25639 PMID: 21980514


Do you know of a great paper that uses SKF 81297 hydrobromide from Tocris? Please let us know.

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SKF81297, a selective D1 receptor agonist.
By Xiangping Chu on 01/04/2018
Assay Type: In Vitro
Species: Human

We used SKF81297 at a concentration of 10 µM/L to active dopamine D1 receptor in cultured mouse striatal neuron.

It is very easy to dissolve the product


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