SKF 81297 hydrobromide

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Cat.No. 1447 - SKF 81297 hydrobromide | C16H16ClNO2.HBr | CAS No. 67287-39-2
Description: D1 agonist
Chemical Name: (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Literature

Biological Activity

Dopamine D1-like receptor agonist. Centrally active following systemic administration in vivo.

Compound Libraries

SKF 81297 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 370.67
Formula C16H16ClNO2.HBr
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 67287-39-2
PubChem ID 11957706
InChI Key RMIJGBMRNYUZRG-UHFFFAOYSA-N
Smiles Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.07 100
water 3.71 10

Preparing Stock Solutions

The following data is based on the product molecular weight 370.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.49 mL 26.98 mL
5 mM 0.54 mL 2.7 mL 5.4 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Arnt et al (1988) Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. Pharmacol.Toxicol. 62 121 PMID: 3259694

Peacock et al (1990) The effects of dopamine D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur.J.Pharmacol. 186 49 PMID: 1980891

Reavill et al (1993) Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297. Behav.Pharmacol. 4 135 PMID: 11224180


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Keywords: D1 agonists Dopamine Receptors D5 dopaminergic SKF81297 hydrobromide D1 and D5 Receptors

8 Citations for SKF 81297 hydrobromide

Citations are publications that use Tocris products. Selected citations for SKF 81297 hydrobromide include:

Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Neurosci 7 624 PMID: 21785426

Deng et al (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. PLoS One 13 1128 PMID: 20711186

Meunier et al (2015) Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex. PLoS One 10 e0120286 PMID: 25775449

Pezze et al (2015) Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Mol Med Rep 232 2669 PMID: 25820982

Parnaudeau et al (2014) Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine. Front Behav Neurosci 8 35 PMID: 24574986

Marley et al (2013) GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. Psychopharmacology (Berl) 8 e70857 PMID: 23936473

Olianas et al (2012) Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex. Neurosignals 21 61 PMID: 22456324

Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823 PMID: 22639870


Do you know of a great paper that uses SKF 81297 hydrobromide from Tocris? If so please let us know.

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Pathways for SKF 81297 hydrobromide

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