(R)-(-)-Apomorphine hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2073 - (R)-(-)-Apomorphine hydrochloride | C17H17NO2.HCl | CAS No. 314-19-2
Description: Dopamine agonist; non-subtype-selective
Chemical Name: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.

Technical Data

M. Wt 303.79
Formula C17H17NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 314-19-2
PubChem ID 9410
InChI Key SKYZYDSNJIOXRL-BTQNPOSSSA-N
Smiles OC1=C2C(C[C@]4([H])C3=C2C=CC=C3CCN4C)=CC=C1O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.38 100
water 13.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 303.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.92 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Liu et al (1996) Low doses of apomorphine suppress operant motor performance in rats. Pharmacol.Biochem.Behav. 53 335 PMID: 8808141

Grunblatt et al (1999) Apomorphine protects against MPTP-induced neurotoxicity in mice. Mov.Disord. 14 612 PMID: 10435498

Millan et al (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J.Pharmacol.Exp.Ther. 303 791 PMID: 12388666


If you know of a relevant reference for (R)-(-)-Apomorphine hydrochloride, please let us know.

View Related Products by Product Action

View all Non-selective Dopamine Agonists

Keywords: (R)-(-)-Apomorphine hydrochloride, supplier, Dopamine, agonists, non-subtype-selective, D2, D3, D4, Non-Selective, Receptors, D1, D5, dopaminergic, Non-selective, Dopamine, Tocris Bioscience

Citations for (R)-(-)-Apomorphine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for (R)-(-)-Apomorphine hydrochloride. Do you know of a great paper that uses (R)-(-)-Apomorphine hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for (R)-(-)-Apomorphine hydrochloride

Protocols

TODO: Add Protocols