You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for LTURM 34
LTURM 34 is a potent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.
Technical Data for LTURM 34
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LTURM 34
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LTURM 34
The following data is based on the product molecular weight 414.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.83 mL||24.13 mL||48.25 mL|
|2.5 mM||0.97 mL||4.83 mL||9.65 mL|
|5 mM||0.48 mL||2.41 mL||4.83 mL|
|25 mM||0.1 mL||0.48 mL||0.97 mL|
References for LTURM 34
References are publications that support the biological activity of the product.
Morrison et al (2016) Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 110 326 PMID: 26854431
If you know of a relevant reference for LTURM 34, please let us know.
View Related Products by Product Action
Keywords: LTURM 34, LTURM 34 supplier, LTURM34, potent, DNA-PK, inhibitors, inhibits, DAN-dependent, protein, kinases, DNA-dependent, Protein, Kinase, 5834, Tocris Bioscience
Citations for LTURM 34
Citations are publications that use Tocris products.
Currently there are no citations for LTURM 34. Do you know of a great paper that uses LTURM 34 from Tocris? Please let us know.
Reviews for LTURM 34
There are currently no reviews for this product. Be the first to review LTURM 34 and earn rewards!
Have you used LTURM 34?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.