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Cat.No. 5834 - LTURM 34 | C24H18N2O3S | CAS No. 1879887-96-3
Description: Potent DNA-PK inhibitor
Chemical Name: 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for LTURM 34

LTURM 34 is a potent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.

Technical Data for LTURM 34

M. Wt 414.48
Formula C24H18N2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1879887-96-3
PubChem ID 122705987
Smiles O=C1C2=C(C(C3=CC=CC4=C3SC5=C4C=CC=C5)=CC=C2)OC(N6CCOCC6)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LTURM 34

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.72 50

Preparing Stock Solutions for LTURM 34

The following data is based on the product molecular weight 414.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.83 mL 24.13 mL 48.25 mL
2.5 mM 0.97 mL 4.83 mL 9.65 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

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References for LTURM 34

References are publications that support the biological activity of the product.

Morrison et al (2016) Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 110 326 PMID: 26854431

If you know of a relevant reference for LTURM 34, please let us know.

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Citations for LTURM 34

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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.