Discontinued Product

LTURM 34 (Cat. No. 5834) has been withdrawn from sale for commercial reasons.
Description: Potent DNA-PK inhibitor
Chemical Name: 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for LTURM 34

LTURM 34 is a potent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.

Technical Data for LTURM 34

M. Wt 414.48
Formula C24H18N2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1879887-96-3
PubChem ID 122705987
Smiles O=C1C2=C(C(C3=CC=CC4=C3SC5=C4C=CC=C5)=CC=C2)OC(N6CCOCC6)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for LTURM 34

References are publications that support the biological activity of the product.

Morrison et al (2016) Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 110 326 PMID: 26854431

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Citations for LTURM 34

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Currently there are no citations for LTURM 34.

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Literature in this Area

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