Y-27632 dihydrochloride

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Description: Y-27632 synthesized to cGMP guidelines
Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥99%
Citations (3)
Protocols (4)
Literature (4)

Biological Activity for Y-27632 dihydrochloride

Y-27632 dihydrochloride is a Y-27632 synthesized to cGMP guidelines. Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.

For more information about how Y-27632 may be used, please see our protocols: Transdifferentiating Fibroblasts into Neurons, Converting Fibroblasts into Cardiomyocytes (9C Cocktail), Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts.

Research use only Y-27632 also available.

Current Good Manufacturing Practice (cGMP) is a harmonized set of guidelines that when implemented will ensure safe, reliable, consistent and quality-assured products. The Tocris range of cGMP small molecules is manufactured following relevant sections of ICH Q7 guidelines. Our highly skilled team has full control over the cGMP process, meaning we can ensure: a quality-assured manufacturing system, batch-to-batch consistency, consistent supply, traceability from starting material to final product, and animal-free production. Find out more about the Tocris range of cGMP compounds.

Technical Data for Y-27632 dihydrochloride

M. Wt 320.26
Formula C14H21N3O.2HCl
Storage Store at RT
Purity ≥99%
CAS Number 129830-38-2
Smiles N[C@H](C)[C@@]1([H])CC[C@H](C(NC2=CC=NC=C2)=O)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

This product is intended for research use or further manufacturing only.

Product Datasheets for Y-27632 dihydrochloride

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for Y-27632 dihydrochloride

References are publications that support the biological activity of the product.

If you know of a relevant reference for Y-27632 dihydrochloride, please let us know.

Keywords: Y-27632 dihydrochloride, Y-27632 dihydrochloride supplier, cGMP, Good, Manufacturing, Practice, Process, Selective, p160ROCK, inhibitors, inhibits, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, ROCK, ROK, stem, cells, organoids, GMP, Small, Molecules, TB1254-GMP, Tocris Bioscience

3 Citations for Y-27632 dihydrochloride

Citations are publications that use Tocris products. Selected citations for Y-27632 dihydrochloride include:

Gantner et al (2020) An optimized protocol for the generation of midbrain dopamine neurons under defined conditions. STAR Protoc. 1 100065 PMID: 33111103

Ma et al (2021) Generation of an iPSC line (SMCPGi001-A) from a patient with Bain type X-linked mental retardation syndrome carrying HNRNPH2 gene mutation. Stem Cell Res. 57 102571 PMID: 34763229

Guo et al (2021) Establishment of an induced pluripotent stem cell line (ZJSHi001-A) from a patient with epileptic encephalopathy carrying KCNB1 Glu330Asp mutation. Stem Cell Res. 52 102224 PMID: 33607466

Do you know of a great paper that uses Y-27632 dihydrochloride from Tocris? Please let us know.

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Protocols for Y-27632 dihydrochloride

The following protocols feature additional information for the use of Y-27632 dihydrochloride (Cat. No. TB1254-GMP).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.