You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Omipalisib
Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro. Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.
Technical Data for Omipalisib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Omipalisib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Omipalisib
The following data is based on the product molecular weight 505.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.89 mL||49.46 mL||98.91 mL|
|1 mM||1.98 mL||9.89 mL||19.78 mL|
|2 mM||0.99 mL||4.95 mL||9.89 mL|
|10 mM||0.2 mL||0.99 mL||1.98 mL|
References for Omipalisib
References are publications that support the biological activity of the product.
Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39 PMID: 24900173
If you know of a relevant reference for Omipalisib, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Omipalisib, Omipalisib supplier, PI, 3-Kinase, PI3K, mTOR, DNA-PK, highly, potent, inhibitors, inhibits, orally, bioavailable, anticancer, GSK2126458, DNA-dependent, Protein, Kinase, 6792, Tocris Bioscience
Citations for Omipalisib
Citations are publications that use Tocris products.
Currently there are no citations for Omipalisib. Do you know of a great paper that uses Omipalisib from Tocris? Please let us know.
Reviews for Omipalisib
There are currently no reviews for this product. Be the first to review Omipalisib and earn rewards!
Have you used Omipalisib?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.