RSK

Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Products
Background
Literature
Gene Data

Inhibitors

Cat. No. Product Name / Activity
4037 BRD 7389
Ribosomal S6 kinase inhibitor
4690 Fmk
Irreversible ribosomal S6 kinase 1/2 inhibitor
3603 Kaempferol
RSK2 inhibitor; blocks histone H3Ser10 phosphorylation
6754 LJI308
Potent pan-RSK inhibitor
4032 PF 4708671
S6K1 inhibitor
5909 RMM 46
MSK/RSK family kinase inhibitor
2250 SL 0101-1
Selective ribosomal S6 kinase (RSK) inhibitor

Other

Cat. No. Product Name / Activity
1292 Rapamycin
Immunosuppressive agent; inhibits p70 S6K activation

Related Targets

    Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cell growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies: p90 RSK and p70 S6K.

    p90 RSKs phosphorylate numerous cytosolic and nuclear targets and act as downstream effectors of the ERK/MAPK signaling cascade. The four isoforms of this enzyme are expressed ubiquitously in human tissues and exist in multiple subcellular compartments. p90 RSKs are activated in response to growth factors, many polypeptide hormones, neurotransmitters and chemokines. Aberrant activation of p90 RSKs has been linked to many human diseases, including breast and prostate cancers.

    p70 ribosomal S6 kinase (S6K) exists as two isoforms − S6K1 and S6K2 − which are activated by mitogenic stimuli such as growth factors, insulin and cytokines. In turn, p70 S6K phosphorylates the ribosomal protein S6. The S6K1 isoform also phosphorylates other proteins involved in the cell's translational machinery, including elF4B (initiation factor); eEF2K (elongation factor 2 kinase); and SKAR (RNA binding protein). As such, it is thought that S6K1 may be directly involved in cell growth and when considered alongside its position downstream of the PI3K and mTOR pathways, this activity makes S6K1 a potential target for cancer therapy.

    External sources of pharmacological information for RSK :

      Literature for RSK

      Tocris offers the following scientific literature for RSK to showcase our products. We invite you to request* or download your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.


      Kinases

      Kinases Product Listing

      A collection of over 400 products for kinase research, the listing includes inhibitors of:

      • Receptor Tyrosine Kinases
      • Protein Kinases A, C, D and G
      • PI-3 Kinase, Akt and mTOR
      • MAPK Signaling
      • Receptor Serine/Threonine Kinases

      Ribosomal S6 Kinase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      RSK1 Human RPS6KA1 NM_002953 Q15418
      Mouse Rps6ka1 NM_009097 P18653
      Rat Rps6ka1 NM_031107 Q63531
      RSK2 Human RPS6KA3 NM_004586 P51812
      Mouse Rps6ka3 NM_148945 P18654
      Rat Rps6ka3 XM_576965 XP_576965
      RSK3 Human RPS6KA2 NM_021135 Q15349
      Mouse Rps6ka2 NM_011299 Q9WUT3
      Rat Rps6ka2 XM_341758 Q9Z1I2
      RSK4 Human RPS6KA6 NM_014496 Q9UK32
      Mouse Rps6ka6 NM_025949 Q7TPS0
      Rat Rps6ka6 XM_228473 XP_228473
      S6K1 Human RPS6KB1 NM_003161 M60724
      Mouse Rps6kb1 NM_001114334 Q8BSK8
      Rat Rps6kb1 NM_031985 P67999
      S6K2 Human RPS6KB2 NM_003952 AB019245
      Mouse Rps6kb2 NM_021485 Q9Z1M4
      Rat Rps6kb2 NM_00101962 AAH89102