AMPK

AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of α- (catalytic) and β/γ- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
3093 Dorsomorphin dihydrochloride
Potent AMPK inhibitor; also BMP type I receptor inhibitor
6475 SU 6656
AMPK inhibitor; also potent ATP-competitive Src family kinase inhibitor; cell permeable

Substrates

Cat No Product Name / Activity
1344 SAMS Peptide
AMP-activated protein kinase substrate

Activators

Cat No Product Name / Activity
3336 A 769662
Potent AMPK activator
2840 AICAR
AMPK activator
3713 Cryptotanshinone
Activates AMPK. Also displays multiple other activities
2864 Metformin hydrochloride
Activator of LKB1/AMPK; antidiabetic agent
6114 PF 06409577
Potent and selective allosteric activator of AMPK
4039 PT 1
AMPK activator
5138 RSVA 405
AMPK activator; also STAT3 inhibitor
5285 ZLN 024 hydrochloride
Allosteric AMPK activator

AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of α- (catalytic) and β/γ- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis. The long-term activation of AMPK increases the capacity of cells to produce ATP.

AMPK is regulated by phosphorylation at the Thr-172 residue of the α-subunit by AMPKK and by phosphorylation by calmodulin-dependent protein kinase kinase-β (CamKKβ). In addition, the ratio of AMP:ATP mediates allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in metabolically active tissues such as the skeletal muscles and liver.

External sources of pharmacological information for AMPK :

Literature for AMPK

Tocris offers the following scientific literature for AMPK to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for AMPK

AMPK

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.

AMPK Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AMPKα1 Human PRKAA1 NM_006251 Q13131
Mouse Prkaa1 NM_001013367 Q5EG47
Rat Prkaa1 NM_019142 P54645
AMPKα2 Human PRKAA2 NM_006252 P54646
Mouse Prkaa2 NM_178143 Q8BRK8
Rat Prkaa2 NM_023991 Q09137
AMPKβ1 Human PRKAB1 NM_006253 Q9Y478
Mouse Prkab1 NM_031869 Q9R078
Rat Prkab1 NM_031976 P80386
AMPKβ2 Human PRKAB2 NM_005399 O43741
Mouse Prkab2 NM_182997 Q6PAM0
Rat Prkab2 NM_022627 Q6AYZ8
AMPKγ1 Human PRKAG1 NM_002733 P54619
Mouse Prkag1 NM_016781 O54950
Rat Prkag1 NM_013010 P80385
AMPKγ2 Human PRKAG2 NM_016203 Q9UGJ0
Mouse Prkag2 NM_145401 Q91WG5
Rat Prkag2 NM_184051 Q4QRB9
AMPKγ3 Human PRKAG3 NM_017431 Q9UGI9
Mouse Prkag3 NM_153745 Q8BGM7
Rat Prkag3 NM_001106921 XP_237293