AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of α- (catalytic) and β/γ- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.
AMPK Inhibitors |
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Cat. No. | Product Name / Activity |
3093 | Dorsomorphin dihydrochloride |
Potent AMPK inhibitor; also BMP type I receptor inhibitor | |
6475 | SU 6656 |
AMPK inhibitor; also potent ATP-competitive Src family kinase inhibitor; cell permeable | |
AMPK Activators |
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Cat. No. | Product Name / Activity |
3336 | A 769662 |
Potent AMPK activator | |
2840 | AICAR |
AMPK activator | |
7685 | IND 1316 |
AMPK activator | |
2864 | Metformin hydrochloride |
Activator of LKB1/AMPK; antidiabetic agent | |
6114 | PF 06409577 |
Potent and selective allosteric activator of AMPK | |
1965 | Simvastatin |
AMPK activator; also HMG-CoA reductase inhibitor | |
5285 | ZLN 024 hydrochloride |
Allosteric AMPK activator |
AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of α- (catalytic) and β/γ- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis. The long-term activation of AMPK increases the capacity of cells to produce ATP.
AMPK is regulated by phosphorylation at the Thr-172 residue of the α-subunit by AMPKK and by phosphorylation by calmodulin-dependent protein kinase kinase-β (CamKKβ). In addition, the ratio of AMP:ATP mediates allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in metabolically active tissues such as the skeletal muscles and liver.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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AMPKα1 | Human | PRKAA1 | NM_006251 | Q13131 |
Mouse | Prkaa1 | NM_001013367 | Q5EG47 | |
Rat | Prkaa1 | NM_019142 | P54645 | |
AMPKα2 | Human | PRKAA2 | NM_006252 | P54646 |
Mouse | Prkaa2 | NM_178143 | Q8BRK8 | |
Rat | Prkaa2 | NM_023991 | Q09137 | |
AMPKβ1 | Human | PRKAB1 | NM_006253 | Q9Y478 |
Mouse | Prkab1 | NM_031869 | Q9R078 | |
Rat | Prkab1 | NM_031976 | P80386 | |
AMPKβ2 | Human | PRKAB2 | NM_005399 | O43741 |
Mouse | Prkab2 | NM_182997 | Q6PAM0 | |
Rat | Prkab2 | NM_022627 | Q6AYZ8 | |
AMPKγ1 | Human | PRKAG1 | NM_002733 | P54619 |
Mouse | Prkag1 | NM_016781 | O54950 | |
Rat | Prkag1 | NM_013010 | P80385 | |
AMPKγ2 | Human | PRKAG2 | NM_016203 | Q9UGJ0 |
Mouse | Prkag2 | NM_145401 | Q91WG5 | |
Rat | Prkag2 | NM_184051 | Q4QRB9 | |
AMPKγ3 | Human | PRKAG3 | NM_017431 | Q9UGI9 |
Mouse | Prkag3 | NM_153745 | Q8BGM7 | |
Rat | Prkag3 | NM_001106921 | XP_237293 |