AMPK

AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of α- (catalytic) and β/γ- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis. The long-term activation of AMPK increases the capacity of cells to produce ATP.

AMPK is regulated by phosphorylation at the Thr-172 residue of the α-subunit by AMPKK and by phosphorylation by calmodulin-dependent protein kinase kinase-β (CamKKβ). In addition, the ratio of AMP:ATP mediates allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in metabolically active tissues such as the skeletal muscles and liver.

External sources of pharmacological information for AMPK :

• IUPHAR Receptor Code

• BJP Guide

Literature for AMPK

Tocris offers the following scientific literature for AMPK to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

• Receptor Tyrosine Kinases
• Protein Kinases A, C, D and G
• PI-3 Kinase, Akt and mTOR
• MAPK Signaling
• Receptor Serine/Threonine Kinases

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Pathways for AMPK

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.

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AMPK Gene Data