mTOR (mammalian target of Rapamycin) integrates signals both intercellularly and extracellularly to regulate growth, proliferation, metabolism and survival. It can form two complexes within the cell, known as mTORC1 and mTORC2 which are dependent on their regulatory proteins Raptor and Rictor respectively. mTOR is important for both the Akt and insulin signal transduction pathways and is deregulated in cancer and Type 2 diabetes.
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