Checkpoint Control Kinases
Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed.
Inhibitors |
|
|---|---|
| Cat No | Product Name / Activity |
| 5198 | AZ 20 |
| Potent and selective ATR kinase inhibitor; antitumor | |
| 3994 | AZ 3146 |
| Potent and selective Mps1 inhibitor | |
| 5199 | AZD 7762 hydrochloride |
| Potent and selective ATP-competitive inhibitor of Chk1 and Chk2 | |
| 4968 | CCT 241533 dihydrochloride |
| Potent Chk2 inhibitor | |
| 3271 | Compound 401 |
| Selective DNA-PK and mTOR inhibitor | |
| 2088 | DMNB |
| DNA-PK inhibitor | |
| 4840 | KU 0060648 |
| Dual DNA-PK and PI 3-K inhibitor | |
| 3544 | KU 55933 |
| Potent and selective ATM kinase inhibitor | |
| 4176 | KU 60019 |
| Potent ATM kinase inhibitor | |
| 3190 | Mirin |
| MRN-ATM pathway inhibitor | |
| 5562 | Mps BAY 2a |
| Potent and selective Mps1 kinase inhibitor | |
| 5142 | Mps1-IN-1 dihydrochloride |
| Selective Mps1 kinase inhibitor | |
| 3034 | NSC 109555 ditosylate |
| Selective Chk2 inhibitor | |
| 2828 | NU 7026 |
| Selective DNA-PK inhibitor | |
| 3712 | NU 7441 |
| Potent and selective DNA-PK inhibitor | |
| 3785 | PD 166285 dihydrochloride |
| Wee1 inhibitor; also inhibits Src, FGFR and PDGFRβ | |
| 2694 | PD 407824 |
| Selective inhibitor of Chk1 and Wee1 | |
| 4277 | PF 477736 |
| Selective Chk1 inhibitor | |
| 3140 | PHA 767491 hydrochloride |
| Dual cdc7/cdk9 inhibitor. Also inhibits MK2 | |
| 2930 | PI 103 hydrochloride |
| Inhibitor of DNA-PK, mTOR and PI 3-kinase | |
| 2560 | SB 218078 |
| Inhibitor of checkpoint kinase 1 (Chk1) | |
| 4750 | TC Mps1 12 |
| Potent and selective Mps1 kinase inhibitor; orally active | |
| 3038 | TCS 2312 |
| Potent Chk1 inhibitor | |
Other |
|
| Cat No | Product Name / Activity |
| 4502 | DIM |
| Activates Chk2; induces G2/M cell cycle arrest | |
| 4763 | Pyridostatin pentahydrochloride |
| Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest | |
Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed. Checkpoint control kinases function to halt the cell cycle at these critical points. Examples of checkpoint control kinases include ATM, ATR, DNA-PK, Chk1, Chk2, Wee1 and mTOR.
For a cell to progress through the cycle and replicate, it must pass through checkpoints between phases to ensure that DNA is replicated correctly and that chromosomes segregate. These checkpoints may stop the cell cycle after DNA damage, loss of DNA replication or disruption of the mitotic spindle, in order for repair processes to take place. If cells containing damaged DNA were to divide, the errors would be transmitted to daughter cells, generating genomic instability and resulting in tumorigenesis or apoptosis.
Literature for Checkpoint Control Kinases
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Checkpoint Control Kinase Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| ATM | Human | ATM | NM_000051 | Q13315 |
| Mouse | Atm | NM_007499 | Q62388 | |
| Rat | Atm | NM_001106821 | NP_001100291 | |
| ATR | Human | ATR | NM_001184 | Q13535 |
| Mouse | Atr | NM_019864 | Q9JKK8 | |
| Rat | Atr | XM_236563 | - | |
| DNA-PK | Human | PRKDC | NM_001081640 | Q9UME3 |
| Mouse | Prkdc | NM_011159 | P97313 | |
| Chk1 | Human | CHEK1 | NM_001274 | O14757 |
| Mouse | Chek1 | NM_007691 | O35280 | |
| Rat | Chek1 | NM_080400 | Q91ZN7 | |
| Chk2 | Human | CHEK2 | NM_001005735 | O96017 |
| Mouse | Chek2 | NM_016681 | Q9Z265 | |
| Rat | Chek2 | NM_053677 | Q9R019 | |
| Wee1 | Human | WEE1 | NM_003390 | P30291 |
| Mouse | Wee1 | NM_009516 | P47810 | |
| Rat | Wee1 | NM_001012742 | Q63802 | |
| mTOR | Human | FRAP1 | NM_004958 | P42345 |
| Mouse | Frap1 | NM_020009 | Q9JLN9 | |
| Rat | Frap1 | NM_019906 | P42346 |
Our Cancer Research Guide highlights over 750 products for cancer research.
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Our Kinase listing highlights over 400 products for kinase research.
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Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Request copyDownload PDF