AZD 8055

Pricing Availability   Qty
Description: Highly potent and selective mTOR inhibitor
Chemical Name: 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity for AZD 8055

AZD 8055 is a highly potent, selective and ATP-competitive mTOR inhibitor (IC50 = 0.8 nM). Inhibits growth and induces autophagy in a range of cancer cell lines and xenografts, including NSCLC and glioblastoma (IC50 values are 20, 50 and 53 nM in H838, A549 and U87MG cell lines, respectively). Orally bioavailable.

Technical Data for AZD 8055

M. Wt 465.55
Formula C25H31N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1009298-09-2
PubChem ID 25262965
InChI Key KVLFRAWTRWDEDF-IRXDYDNUSA-N
Smiles C[C@@H]1N(CCOC1)C2=NC(N3[C@H](COCC3)C)=NC4=C2C=CC(C5=CC(CO)=C(C=C5)OC)=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 8055

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.55 100
ethanol 9.31 20

Preparing Stock Solutions for AZD 8055

The following data is based on the product molecular weight 465.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References for AZD 8055

References are publications that support the biological activity of the product.

Chresta et al (2010) AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 70 288 PMID: 20028854


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Keywords: AZD 8055, AZD 8055 supplier, AZD8055, highly, potent, selective, ATP-competitive, mtor, inhibitor, inhibitors, autophagy, cancer, mTOR, 7840, Tocris Bioscience

Citations for AZD 8055

Citations are publications that use Tocris products.

Currently there are no citations for AZD 8055. Do you know of a great paper that uses AZD 8055 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for AZD 8055

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.