Selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.
Sold for research purposes only under agreement from KUDOS
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Garcia-Martinez et al (2009) Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 421 29 PMID: 19402821
If you know of a relevant reference for KU 0063794, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: KU0063794 mammalian target of rapamycin inhibitors inhibits selective mTOR kinases suppresses cell growth mTOR
7 Citations for KU 0063794
Citations are publications that use Tocris products. Selected citations for KU 0063794 include:
Hukelmann et al (2016) The cytotoxic T cell proteome and its shaping by the kinase mTOR. J Biol Chem 17 104 PMID: 26551880
López-Cotarelo et al (2015) A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. Proc Natl Acad Sci U S A 290 827 PMID: 25425646
Munson et al (2015) mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. Nat Immunol 34 2272 PMID: 26139536
Wang et al (2014) SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One 8 e83941 PMID: 24391850
Fei et al (2013) Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. PLoS One 8 e69104 PMID: 23874880
Sengupta et al (2013) Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Free Radic Biol Med 110 18826 PMID: 24191005
Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. EMBO J 64 4361 PMID: 23963679
Do you know of a great paper that uses KU 0063794 from Tocris? If so please let us know.