Selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.48 mL||107.4 mL||214.8 mL|
|0.5 mM||4.3 mL||21.48 mL||42.96 mL|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
References are publications that support the biological activity of the product.
Garcia-Martinez et al (2009) Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 421 29 PMID: 19402821
If you know of a relevant reference for KU 0063794, please let us know.
View Related Products by Product Action
Keywords: KU 0063794, KU 0063794 supplier, KU0063794, mammalian, target, of, rapamycin, inhibitors, inhibits, selective, mTOR, kinases, suppresses, cell, growth, 3725, Tocris Bioscience
8 Citations for KU 0063794
Citations are publications that use Tocris products. Selected citations for KU 0063794 include:
Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. EMBO J 64 4361 PMID: 23963679
Wang et al (2014) SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One 8 e83941 PMID: 24391850
Sengupta et al (2013) Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Free Radic Biol Med 110 18826 PMID: 24191005
Hukelmann et al (2016) The cytotoxic T cell proteome and its shaping by the kinase mTOR. J Biol Chem 17 104 PMID: 26551880
López-Cotarelo et al (2015) A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. Proc Natl Acad Sci U S A 290 827 PMID: 25425646
Munson et al (2015) mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. Nat Immunol 34 2272 PMID: 26139536
Fei et al (2013) Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. PLoS One 8 e69104 PMID: 23874880
Gandin et al (2016) mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun 7 11127 PMID: 27040916
Do you know of a great paper that uses KU 0063794 from Tocris? Please let us know.
Reviews for KU 0063794
There are currently no reviews for this product. Be the first to review KU 0063794 and earn rewards!
Have you used KU 0063794?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.