Disulfiram

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Cat.No. 3807 - Disulfiram | C10H20N2S4 | CAS No. 97-77-8
Description: Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities
Alternative Names: Tetraethylthiuram disulfide
Chemical Name: Bis(diethylthiocarbamyoyl)disulfide
Datasheet
Citations (1)

Biological Activity

Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.

Technical Data

M. Wt 296.54
Formula C10H20N2S4
Storage Store at +4°C
CAS Number 97-77-8
PubChem ID 3117
InChI Key AUZONCFQVSMFAP-UHFFFAOYSA-N
Smiles S=C(SSC(N(CC)CC)=S)N(CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.93 20
ethanol 29.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 296.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.86 mL 33.72 mL
5 mM 0.67 mL 3.37 mL 6.74 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Starling et al (1996) Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disulfiram. Biochem.J. 320 101 PMID: 8947473

Cho et al (2007) Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J.Biochem.Mol.Biol. 40 1069 PMID: 18047805

Johnson et al (2009) Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Anal.Biochem. 398 203 PMID: 20018164

Fisher et al (2010) The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo. J.Pharmacol.Exp.Ther. 332 326 PMID: 19820208


If you know of a relevant reference for Disulfiram, please let us know.

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Keywords: Disulfiram, supplier, aldehyde, dehydrogenase, inhibitors, inhibits, anti-alcoholism, stimulates, stimulators, reversible, ca2+-atpase, V-atpase, vacuolar, atpase, MMP, matrix, metalloproteinase, metalloprotease, MMP-2, MMP-9, proteinase, protease, Tetraethylthiuram, disulfide, Ca2+-ATPase, Tocris Bioscience

1 Citation for Disulfiram

Citations are publications that use Tocris products. Selected citations for Disulfiram include:

Chan et al (2016) HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells. PLoS One 13 1 PMID: 26728316


Do you know of a great paper that uses Disulfiram from Tocris? If so please let us know.

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