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Biological Activity for WAY 170523
WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).
Compound Libraries for WAY 170523
Technical Data for WAY 170523
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WAY 170523
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for WAY 170523
The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.15 mL||16.3 mL|
|5 mM||0.33 mL||1.63 mL||3.26 mL|
|10 mM||0.16 mL||0.81 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
References for WAY 170523
References are publications that support the biological activity of the product.
Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648
Jaffré et al (2012) beta -adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125 2993 PMID: 22610965
If you know of a relevant reference for WAY 170523, please let us know.
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Citations for WAY 170523
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Literature in this Area
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