WAY 170523

Pricing Availability Delivery Time Qty
Cat.No. 2633 - WAY 170523 | C33H31N3O7S | CAS No. 307002-73-9
Description: Potent and selective inhibitor of MMP-13
Chemical Name: N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).

Compound Libraries

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Technical Data

M. Wt 613.68
Formula C33H31N3O7S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 307002-73-9
PubChem ID 9830392
InChI Key FARMEEAGJWMFSZ-UHFFFAOYSA-N
Smiles CC1=CC(C(=O)NO)=C(N(CC2=CC=CC=C2)S(=O)(=O)C2=CC=C(OCCNC(=O)C3=CC4=CC=CC=C4O3)C=C2)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.37 100
ethanol 61.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.15 mL 16.3 mL
5 mM 0.33 mL 1.63 mL 3.26 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648 PMID:

Jaffré et al (2012) beta -adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125 2993 PMID: 22610965


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Citations for WAY 170523

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