WAY 170523

Pricing Availability   Qty
Description: Potent and selective inhibitor of MMP-13
Chemical Name: N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for WAY 170523

WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).

Compound Libraries for WAY 170523

WAY 170523 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 170523

M. Wt 613.68
Formula C33H31N3O7S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 307002-73-9
PubChem ID 9830392
Smiles CC1=CC(C(=O)NO)=C(N(CC2=CC=CC=C2)S(=O)(=O)C2=CC=C(OCCNC(=O)C3=CC4=CC=CC=C4O3)C=C2)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WAY 170523

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 61.37 100
ethanol 61.37 100

Preparing Stock Solutions for WAY 170523

The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.15 mL 16.3 mL
5 mM 0.33 mL 1.63 mL 3.26 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets for WAY 170523

Certificate of Analysis / Product Datasheet
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References for WAY 170523

References are publications that support the biological activity of the product.

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648

Jaffré et al (2012) beta -adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125 2993 PMID: 22610965

If you know of a relevant reference for WAY 170523, please let us know.

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Citations for WAY 170523

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Currently there are no citations for WAY 170523. Do you know of a great paper that uses WAY 170523 from Tocris? Please let us know.

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Literature in this Area

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