Pricing Availability   Qty
Description: ADAM-17 (TACE) and MMP inhibitor
Alternative Names: TNF-α processing inhibitor-0
Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
Purity: ≥95% (HPLC)
Citations (2)
Literature (1)

Biological Activity for TAPI 0

TAPI 0 is an ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.

Technical Data for TAPI 0

M. Wt 456.54
Formula C24H32N4O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 163958-73-4
PubChem ID 3035404
Smiles ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAPI 0

Solubility Soluble to 10 mg/ml in DMSO

Product Datasheets for TAPI 0

Certificate of Analysis / Product Datasheet
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References for TAPI 0

References are publications that support the biological activity of the product.

Balakrishnan et al (2006) Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J.Biol.Chem. 281 16691 PMID: 16565079

Rzeniewicz et al (2015) L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc.Natl.Acad.Sci.USA. 112 E1461 PMID: 25775539

If you know of a relevant reference for TAPI 0, please let us know.

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Keywords: TAPI 0, TAPI 0 supplier, TAPI0, ADAM17, metalloproteases, MMPs, metalloproteinases, inhibits, inhibitors, adams, TNFa, TNFα, converting, enzyme, TACE, TNF-a, processing, inhibitor-0, ADAMs, Matrix, Metalloprotease, 5523, Tocris Bioscience

2 Citations for TAPI 0

Citations are publications that use Tocris products. Selected citations for TAPI 0 include:

Wulf et al (2021) Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. Cells 10 PMID: 34831323

Mina J et al (2020) Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. Cell Syst 11 161-175.e5 PMID: 32726596

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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