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Submit ReviewTAPI 0
Description: ADAM-17 (TACE) and MMP inhibitor
Alternative Names: TNF-α processing inhibitor-0
Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
Purity: ≥95% (HPLC)
Biological Activity
ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.
Technical Data
| M. Wt | 456.54 |
| Formula | C24H32N4O5 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 163958-73-4 |
| PubChem ID | 3035404 |
| InChI Key | CRCPLBFLOSEABN-VBSNWNEZSA-N |
| Smiles | ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N)=O)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 10 mg/ml in DMSO |
Product Datasheets
References
References are publications that support the biological activity of the product.
Balakrishnan et al (2006) Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J.Biol.Chem. 281 16691 PMID: 16565079
Rzeniewicz et al (2015) L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc.Natl.Acad.Sci.USA. 112 E1461 PMID: 25775539
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Citations for TAPI 0
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Reviews for TAPI 0
Average Rating: 4 (Based on 1 Review.)
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In vitro cell treatment.
By
Anonymous on 01/04/2019
Assay Type: In Vitro
Species: Mouse
Cells were treated with 10 um TAPI-0 to study cell surface protein shedding
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