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Biological Activity for TAPI 0
TAPI 0 is an ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.
Technical Data for TAPI 0
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TAPI 0
|Solubility||Soluble to 10 mg/ml in DMSO|
References for TAPI 0
References are publications that support the biological activity of the product.
Balakrishnan et al (2006) Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J.Biol.Chem. 281 16691 PMID: 16565079
Rzeniewicz et al (2015) L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc.Natl.Acad.Sci.USA. 112 E1461 PMID: 25775539
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Keywords: TAPI 0, TAPI 0 supplier, TAPI0, ADAM17, metalloproteases, MMPs, metalloproteinases, inhibits, inhibitors, adams, TNFa, TNFα, converting, enzyme, TACE, TNF-a, processing, inhibitor-0, ADAMs, Matrix, Metalloprotease, 5523, Tocris Bioscience
2 Citations for TAPI 0
Citations are publications that use Tocris products. Selected citations for TAPI 0 include:
Wulf et al (2021) Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. Cells 10 PMID: 34831323
Mina J et al (2020) Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. Cell Syst 11 161-175.e5 PMID: 32726596
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Reviews for TAPI 0
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Literature in this Area
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