UK 370106

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Cat.No. 2900 - UK 370106 | C35H44N2O5 | CAS No. 230961-21-4
Description: Highly selective MMP-3 and MMP-12 inhibitor
Chemical Name: (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.

Technical Data

M. Wt 572.73
Formula C35H44N2O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 230961-21-4
PubChem ID 9808181
InChI Key NSMABJUGSNPHMN-BHYWQNONSA-N
Smiles CC(C=C(CCC[C@@H](C(N[C@@H]([C@@](C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O)=O)CC(O)=O)C=C2)=C2C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.27 100
ethanol 14.32 25

Preparing Stock Solutions

The following data is based on the product molecular weight 572.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.75 mL 8.73 mL 17.46 mL
5 mM 0.35 mL 1.75 mL 3.49 mL
10 mM 0.17 mL 0.87 mL 1.75 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fray et al (2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 46 3514 PMID: 12877590

Whitlock et al (2007) A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts. 17 6750 PMID:

Matthews et al (2008) Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics 356 110 PMID:


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1 Citation for UK 370106

Citations are publications that use Tocris products. Selected citations for UK 370106 include:

Agren et al (2015) Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. J Biol Chem 94 44531 PMID: 25457675


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