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Biological Activity for UK 370106
UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.
Technical Data for UK 370106
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UK 370106
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for UK 370106
The following data is based on the product molecular weight 572.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.75 mL||8.73 mL||17.46 mL|
|5 mM||0.35 mL||1.75 mL||3.49 mL|
|10 mM||0.17 mL||0.87 mL||1.75 mL|
|50 mM||0.03 mL||0.17 mL||0.35 mL|
References for UK 370106
References are publications that support the biological activity of the product.
Fray et al (2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 46 3514 PMID: 12877590
Whitlock et al (2007) A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts. 17 6750
Matthews et al (2008) Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics 356 110
If you know of a relevant reference for UK 370106, please let us know.
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Keywords: UK 370106, UK 370106 supplier, selective, MMP-3, MMP-12, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, UK370106, 2900, Tocris Bioscience
1 Citation for UK 370106
Citations are publications that use Tocris products. Selected citations for UK 370106 include:
Agren et al (2015) Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. J Biol Chem 94 44531 PMID: 25457675
Do you know of a great paper that uses UK 370106 from Tocris? Please let us know.
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Literature in this Area
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