UK 370106

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Cat.No. 2900 - UK 370106 | C35H44N2O5 | CAS No. 230961-21-4
Description: Highly selective MMP-3 and MMP-12 inhibitor
Chemical Name: (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

Highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.

Technical Data

M. Wt 572.73
Formula C35H44N2O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 230961-21-4
PubChem ID 9808181
InChI Key NSMABJUGSNPHMN-BHYWQNONSA-N
Smiles CC(C=C(CCC[C@@H](C(N[C@@H]([C@@](C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O)=O)CC(O)=O)C=C2)=C2C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.27 100
ethanol 14.32 25

Preparing Stock Solutions

The following data is based on the product molecular weight 572.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.75 mL 8.73 mL 17.46 mL
5 mM 0.35 mL 1.75 mL 3.49 mL
10 mM 0.17 mL 0.87 mL 1.75 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fray et al (2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 46 3514 PMID: 12877590

Whitlock et al (2007) A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts. 17 6750

Matthews et al (2008) Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics 356 110


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View all Matrix Metalloprotease Inhibitors

Keywords: UK 370106, UK 370106 supplier, selective, MMP-3, MMP-12, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, UK370106, 2900, Tocris Bioscience

1 Citation for UK 370106

Citations are publications that use Tocris products. Selected citations for UK 370106 include:

Agren et al (2015) Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. J Biol Chem 94 44531 PMID: 25457675


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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