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Biological Activity for Doxycycline hyclate
Doxycycline hyclate is a broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Doxycycline hyclate increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.
For more information about how Doxycycline hyclate may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Reprogramming MEFs into Skeletal Muscle Progenitors.
Technical Data for Doxycycline hyclate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Doxycycline hyclate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Doxycycline hyclate
The following data is based on the product molecular weight 512.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.95 mL||9.75 mL||19.5 mL|
|5 mM||0.39 mL||1.95 mL||3.9 mL|
|10 mM||0.19 mL||0.97 mL||1.95 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
Product Datasheets for Doxycycline hyclate
References for Doxycycline hyclate
References are publications that support the biological activity of the product.
Franco et al (2006) Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am.J.Pathol. 168 1697 PMID: 16651635
Burggraf et al (2007) Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol.Dis. 25 506 PMID: 17166729
Wernig et al (2008) A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat.Biotechnol. 26 916 PMID: 18594521
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Keywords: Doxycycline hyclate, Doxycycline hyclate supplier, tetracycline, antibiotics, inhibits, MMPs, matrix, metalloprotease, metalloproteinase, inhibitors, Matrix, Metalloprotease, Antibiotics, 4090, Tocris Bioscience
2 Citations for Doxycycline hyclate
Citations are publications that use Tocris products. Selected citations for Doxycycline hyclate include:
Sato et al (2019) Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells. Stem Cell Reports 13 352 PMID: 31353225
Kalous et al (2012) Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem 122 523 PMID: 22621370
Do you know of a great paper that uses Doxycycline hyclate from Tocris? Please let us know.
Reviews for Doxycycline hyclate
Average Rating: 4 (Based on 1 Review.)
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Protocols for Doxycycline hyclate
The following protocols feature additional information for the use of Doxycycline hyclate (Cat. No. 4090).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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