Doxycycline hyclate

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Cat.No. 4090 - Doxycycline hyclate | C22H24N2O8.HCl.0.5C2H6O.0.5H2O | CAS No. 24390-14-5
Description: Broad-spectrum MMP inhibitor; tetracycline derivative
Chemical Name: (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate
Datasheet
Citations (1)
Literature

Biological Activity

Broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.

Compound Libraries

Doxycycline hyclate is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 512.94
Formula C22H24N2O8.HCl.0.5C2H6O.0.5H2O
Storage Store at +4°C
CAS Number 24390-14-5
PubChem ID 54686183
InChI Key UHHHTIKWXBRCLT-VDBOFHIQSA-N
Smiles OC1=C(C(C2=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]4N(C)C)=O)(O)[C@@]4([H])[C@@H](O)[C@@]([H])2[C@H]3C)=O)C3=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.09 100
water 48.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 512.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.75 mL 19.5 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Franco et al (2006) Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am.J.Pathol. 168 1697 PMID: 16651635

Burggraf et al (2007) Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol.Dis. 25 506 PMID: 17166729

Wernig et al (2008) A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat.Biotechnol. 26 916 PMID: 18594521


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View Related Products by Product Action

View all Matrix Metalloprotease Inhibitors

Keywords: tetracycline antibiotics inhibits MMPs matrix metalloprotease metalloproteinase inhibitors Matrix Metalloprotease

1 Citation for Doxycycline hyclate

Citations are publications that use Tocris products. Selected citations for Doxycycline hyclate include:

Kalous et al (2012) Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem 122 523 PMID: 22621370


Do you know of a great paper that uses Doxycycline hyclate from Tocris? If so please let us know.

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Literature in this Area

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Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for Doxycycline hyclate

Protocols

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