Broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 512.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.95 mL||9.75 mL||19.5 mL|
|5 mM||0.39 mL||1.95 mL||3.9 mL|
|10 mM||0.19 mL||0.97 mL||1.95 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Franco et al (2006) Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am.J.Pathol. 168 1697 PMID: 16651635
Burggraf et al (2007) Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol.Dis. 25 506 PMID: 17166729
Wernig et al (2008) A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat.Biotechnol. 26 916 PMID: 18594521
If you know of a relevant reference for Doxycycline hyclate, please let us know.
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Keywords: tetracycline antibiotics inhibits MMPs matrix metalloprotease metalloproteinase inhibitors Matrix Metalloprotease
1 Citation for Doxycycline hyclate
Citations are publications that use Tocris products. Selected citations for Doxycycline hyclate include:
Kalous et al (2012) Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem 122 523 PMID: 22621370
Do you know of a great paper that uses Doxycycline hyclate from Tocris? If so please let us know.