GM 6001

Pricing Availability   Qty
Cat.No. 2983 - GM 6001 | C20H28N4O4 | CAS No. 142880-36-2
Description: Broad spectrum MMP inhibitor
Alternative Names: Galardin, Ilomastat
Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Purity: ≥95% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (4)

Biological Activity for GM 6001

GM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).

Technical Data for GM 6001

M. Wt 388.46
Formula C20H28N4O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 142880-36-2
PubChem ID 132519
InChI Key NITYDPDXAAFEIT-DYVFJYSZSA-N
Smiles O=C(NC)[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)CC2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GM 6001

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.85 100

Preparing Stock Solutions for GM 6001

The following data is based on the product molecular weight 388.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.87 mL 25.74 mL
5 mM 0.51 mL 2.57 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for GM 6001

Certificate of Analysis / Product Datasheet
Select another batch:

References for GM 6001

References are publications that support the biological activity of the product.

Shichi et al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701 PMID: 21602423

Grobelny et al (1992) Inhibition of skin fibroblast Col., thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152 PMID: 1322694

Chao et al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49 PMID: 17678888


If you know of a relevant reference for GM 6001, please let us know.

View Related Products by Product Action

View all Matrix Metalloprotease Inhibitors

Keywords: GM 6001, GM 6001 supplier, GM6001, matrix, metalloproteases, metalloproteinases, MMPs, broad-spectrum, inhibitors, inhibits, Ilomastat, Galardin, Matrix, Metalloprotease, 2983, Tocris Bioscience

10 Citations for GM 6001

Citations are publications that use Tocris products. Selected citations for GM 6001 include:

Luo et al (2018) Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nat Commun 9 4126 PMID: 30297691

Kim et al (2018) Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun 9 4600 PMID: 30389913

Bras et al (2015) TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. PLoS One 330 29 PMID: 25064463

Greene et al (2015) CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells. Proc Natl Acad Sci U S A 10 e0144133 PMID: 26710229


Do you know of a great paper that uses GM 6001 from Tocris? Please let us know.

Reviews for GM 6001

There are currently no reviews for this product. Be the first to review GM 6001 and earn rewards!

Have you used GM 6001?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.