GM 6001

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Cat.No. 2983 - GM 6001 | C20H28N4O4 | CAS No. 142880-36-2
Description: Broad spectrum MMP inhibitor
Alternative Names: Galardin, Ilomastat
Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Purity: ≥95% (HPLC)
Datasheet
Citations (7)
Reviews
Literature

Biological Activity

Broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).

Technical Data

M. Wt 388.46
Formula C20H28N4O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 142880-36-2
PubChem ID 132519
InChI Key NITYDPDXAAFEIT-DYVFJYSZSA-N
Smiles O=C(NC)[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)CC2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 388.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.87 mL 25.74 mL
5 mM 0.51 mL 2.57 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Shichi et al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701 PMID: 21602423

Grobelny et al (1992) Inhibition of skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152 PMID: 1322694

Chao et al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49 PMID: 17678888


If you know of a relevant reference for GM 6001, please let us know.

View Related Products by Product Action

View all Matrix Metalloprotease Inhibitors

Keywords: GM 6001, GM 6001 supplier, GM6001, matrix, metalloproteases, metalloproteinases, MMPs, broad-spectrum, inhibitors, inhibits, Ilomastat, Galardin, Matrix, Metalloprotease, 2983, Tocris Bioscience

7 Citations for GM 6001

Citations are publications that use Tocris products. Selected citations for GM 6001 include:

Sun et al (2017) Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell Physiol Biochem 41 2319 PMID: 28463834

Son et al (2015) Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Mol Neurodegener 10 56 PMID: 26520569

Lahey et al (2017) Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS One 12 e0180259 PMID: 28671992

Schumacher (2017) ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis 8 e2622 PMID: 28230865

Bras et al (2015) TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. PLoS One 330 29 PMID: 25064463

Greene et al (2015) CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells. Proc Natl Acad Sci U S A 10 e0144133 PMID: 26710229

Leung et al (2015) PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. J Immunol 194 2930 PMID: 25687758


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

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