Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.84 mL||19.22 mL||38.44 mL|
|5 mM||0.77 mL||3.84 mL||7.69 mL|
|10 mM||0.38 mL||1.92 mL||3.84 mL|
|50 mM||0.08 mL||0.38 mL||0.77 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Remacle et al (2012) Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72 2339 PMID: 22406620
If you know of a relevant reference for NSC 405020, please let us know.
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Keywords: NSC405020 Membrane type-1 matrix metalloproteinase MT1-MMP inhibitors inhibits hemopexin domains PEX pro-tumorigenic antitumor MMP2 MMP-2 MMP Matrix Metalloprotease
1 Citation for NSC 405020
Citations are publications that use Tocris products. Selected citations for NSC 405020 include:
Clancy et al (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Proc Natl Acad Sci U S A 6 6919 PMID: 25897521
Do you know of a great paper that uses NSC 405020 from Tocris? If so please let us know.