NSC 405020

Pricing Availability Delivery Time Qty
Cat.No. 4902 - NSC 405020 | C12H15Cl2NO | CAS No. 7497-07-6
Description: Inhibitor of MT1-MMP; antitumor
Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

Compound Libraries

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Technical Data

M. Wt 260.16
Formula C12H15Cl2NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 7497-07-6
PubChem ID 346721
Smiles ClC1=CC=C(C(NC(C)CCC)=O)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.02 100
ethanol 26.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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References are publications that support the products' biological activity.

Remacle et al (2012) Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72 2339 PMID: 22406620

If you know of a relevant reference for NSC 405020, please let us know.

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Keywords: NSC 405020, supplier, NSC405020, Membrane, type-1, matrix, metalloproteinase, MT1-MMP, inhibitors, inhibits, hemopexin, domains, PEX, pro-tumorigenic, antitumor, MMP2, MMP-2, MMP, Matrix, Metalloprotease, Matrix, Metalloprotease, Tocris Bioscience

1 Citation for NSC 405020

Citations are publications that use Tocris products. Selected citations for NSC 405020 include:

Clancy et al (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Proc Natl Acad Sci U S A 6 6919 PMID: 25897521

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