SB 3CT

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Cat.No. 6088 - SB 3CT | C15H14O3S2 | CAS No. 292605-14-2
Description: Selective high affinity MMP2 inhibitor
Chemical Name: 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective high affinity MMP2 inhibitor (Ki = 28 nM); also inhibits MMP9 (Ki = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable.

Technical Data

M. Wt 306.4
Formula C15H14O3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 292605-14-2
PubChem ID 9883002
InChI Key LSONWRHLFZYHIN-UHFFFAOYSA-N
Smiles O=S(CC1CS1)(C2=CC=C(C=C2)OC3=CC=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.64 100
ethanol 6.13 20

Preparing Stock Solutions

The following data is based on the product molecular weight 306.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gu et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 25 6401 PMID: 16000631

Kleifeld et al (2001) X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 18 17125 PMID: 11278946

Gooyit et al (2012) Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 3 730 PMID: 23077716


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Citations for SB 3CT

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Literature in this Area

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Pathways for SB 3CT

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