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Biological Activity for SB 3CT
SB 3CT is a selective high affinity MMP2 inhibitor (Ki = 28 nM); also inhibits MMP9 (Ki = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable.
Technical Data for SB 3CT
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SB 3CT
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SB 3CT
The following data is based on the product molecular weight 306.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.26 mL||16.32 mL||32.64 mL|
|5 mM||0.65 mL||3.26 mL||6.53 mL|
|10 mM||0.33 mL||1.63 mL||3.26 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References for SB 3CT
References are publications that support the biological activity of the product.
Gu et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 25 6401 PMID: 16000631
Kleifeld et al (2001) X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 18 17125 PMID: 11278946
Gooyit et al (2012) Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 3 730 PMID: 23077716
If you know of a relevant reference for SB 3CT, please let us know.
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Keywords: SB 3CT, SB 3CT supplier, SB3CT, Selective, high, affinity, MMP2, inhibitors, MMP9, blood-brain, barrier, BBB, permeable, matrix, metalloproteinases, neuroprotective, Matrix, Metalloprotease, 6088, Tocris Bioscience
1 Citation for SB 3CT
Citations are publications that use Tocris products. Selected citations for SB 3CT include:
Lin-Chien et al (2021) Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis. Elife 10 PMID: 34282726
Do you know of a great paper that uses SB 3CT from Tocris? Please let us know.
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Literature in this Area
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