You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.55 mL||27.74 mL||55.49 mL|
|2.5 mM||1.11 mL||5.55 mL||11.1 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|25 mM||0.11 mL||0.55 mL||1.11 mL|
References are publications that support the biological activity of the product.
Scannevin et al (2017) Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J.Biol.Chem. 292 17963 PMID: 28860188
If you know of a relevant reference for JNJ 0966, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JNJ 0966, JNJ 0966 supplier, JNJ0966, Pro-MMP9, activation, inhibitor, zymogen, MMP9, signaling, brain, penetrant, cell, invasion, EAE, experimental, autoimmune, encephalomyelitis, matrix, metalloprotease, Matrix, Metalloprotease, 6439, Tocris Bioscience
Citations for JNJ 0966
Citations are publications that use Tocris products.
Currently there are no citations for JNJ 0966. Do you know of a great paper that uses JNJ 0966 from Tocris? Please let us know.
Reviews for JNJ 0966
There are currently no reviews for this product. Be the first to review JNJ 0966 and earn rewards!
Have you used JNJ 0966?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.