JNJ 0966

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Cat.No. 6439 - JNJ 0966 | C16H16N4O2S2 | CAS No. 315705-75-0
Description: Pro-MMP9 activation inhibitor
Chemical Name: N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.

Technical Data

M. Wt 360.45
Formula C16H16N4O2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 315705-75-0
PubChem ID 1117189
InChI Key ZADCDCMLLGDCRM-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C1)NC2=NC(C3=C(N=C(S3)NC(C)=O)C)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 360.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.55 mL 27.74 mL 55.49 mL
2.5 mM 1.11 mL 5.55 mL 11.1 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
25 mM 0.11 mL 0.55 mL 1.11 mL

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References

References are publications that support the biological activity of the product.

Scannevin et al (2017) Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J.Biol.Chem. 292 17963 PMID: 28860188


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