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Pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.55 mL||27.74 mL||55.49 mL|
|2.5 mM||1.11 mL||5.55 mL||11.1 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|25 mM||0.11 mL||0.55 mL||1.11 mL|
References are publications that support the biological activity of the product.
Scannevin et al (2017) Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J.Biol.Chem. 292 17963 PMID: 28860188
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Keywords: JNJ 0966, JNJ 0966 supplier, JNJ0966, Pro-MMP9, activation, inhibitor, zymogen, MMP9, signaling, brain, penetrant, cell, invasion, EAE, experimental, autoimmune, encephalomyelitis, matrix, metalloprotease, Matrix, Metalloprotease, 6439, Tocris Bioscience
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