ARP 101

Pricing Availability   Qty
Description: Inhibitor of MMP-2
Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for ARP 101

ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).

Technical Data for ARP 101

M. Wt 406.5
Formula C20H26N2O5S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 849773-63-3
PubChem ID 11292680
Smiles O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)[C@H]([C@@H](C)C)C(NO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ARP 101

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.65 100
ethanol 10.16 25

Preparing Stock Solutions for ARP 101

The following data is based on the product molecular weight 406.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for ARP 101

Certificate of Analysis / Product Datasheet
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References for ARP 101

References are publications that support the biological activity of the product.

Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260 PMID: 16483784

If you know of a relevant reference for ARP 101, please let us know.

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Keywords: ARP 101, ARP 101 supplier, inhibitors, inhibits, MMP-2, Matrix, Metalloprotease, Matrixins, Metalloproteinase, MMP, Proteinases, Proteases, ARP101, 2622, Tocris Bioscience

3 Citations for ARP 101

Citations are publications that use Tocris products. Selected citations for ARP 101 include:

Rocha-Azevedo et al (2015) PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2. Hum Reprod 26 1098 PMID: 25589674

Li et al (2013) NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Oncotarget 28 2822 PMID: 23856325

Sun et al (2017) Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell Physiol Biochem 41 2319 PMID: 28463834

Do you know of a great paper that uses ARP 101 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.