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Biological Activity for ARP 101
ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).
Technical Data for ARP 101
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ARP 101
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ARP 101
The following data is based on the product molecular weight 406.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.46 mL||12.3 mL||24.6 mL|
|5 mM||0.49 mL||2.46 mL||4.92 mL|
|10 mM||0.25 mL||1.23 mL||2.46 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References for ARP 101
References are publications that support the biological activity of the product.
Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260 PMID: 16483784
If you know of a relevant reference for ARP 101, please let us know.
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Keywords: ARP 101, ARP 101 supplier, inhibitors, inhibits, MMP-2, Matrix, Metalloprotease, Matrixins, Metalloproteinase, MMP, Proteinases, Proteases, ARP101, 2622, Tocris Bioscience
3 Citations for ARP 101
Citations are publications that use Tocris products. Selected citations for ARP 101 include:
Sun et al (2017) Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell Physiol Biochem 41 2319 PMID: 28463834
Li et al (2013) NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Oncotarget 28 2822 PMID: 23856325
Rocha-Azevedo et al (2015) PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2. Hum Reprod 26 1098 PMID: 25589674
Do you know of a great paper that uses ARP 101 from Tocris? Please let us know.
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Literature in this Area
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