ARP 101

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Cat.No. 2622 - ARP 101 | C20H26N2O5S | CAS No. 849773-63-3
Description: Inhibitor of MMP-2
Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).

Technical Data

M. Wt 406.5
Formula C20H26N2O5S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 849773-63-3
PubChem ID 11292680
InChI Key DGZZVIWCMGVHGV-LJQANCHMSA-N
Smiles O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)[C@H]([C@@H](C)C)C(NO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.65 100
ethanol 10.16 25

Preparing Stock Solutions

The following data is based on the product molecular weight 406.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260 PMID: 16483784


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Keywords: ARP 101, supplier, inhibitors, inhibits, MMP-2, Matrix, Metalloprotease, Matrixins, Metalloproteinase, MMP, Proteinases, Proteases, ARP101, Matrix, Metalloprotease, Tocris Bioscience

2 Citations for ARP 101

Citations are publications that use Tocris products. Selected citations for ARP 101 include:

Rocha-Azevedo et al (2015) PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2. Hum Reprod 26 1098 PMID: 25589674

Li et al (2013) NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Oncotarget 28 2822 PMID: 23856325


Do you know of a great paper that uses ARP 101 from Tocris? If so please let us know.

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Literature in this Area

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Pathways for ARP 101

Protocols

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