Pricing Availability   Qty
Description: ADAM-17 (TACE) and MMP inhibitor
Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)--alanyl-L-alaninamide
Purity: ≥95% (HPLC)
Literature (3)

Biological Activity for TAPI 1

TAPI 1 is a TACE/ADAM-17 and MMP inhibitor. Blocks shedding of TNF from cell membranes. Reduces pain-associated behavior in mice with a constructive mononeuropathy.

This product is typically reconstituted in DMSO.

Technical Data for TAPI 1

M. Wt 499.6
Formula C26H37N5O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 163847-77-6
PubChem ID 9827273
Smiles ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(NCCN)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for TAPI 1

Certificate of Analysis / Product Datasheet
Select another batch:

References for TAPI 1

References are publications that support the biological activity of the product.

Sommer et al (1997) A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. Neurosci. Lett. 237 45 PMID: 9406876

Mohler et al (1994) Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370 218 PMID: 8028669

If you know of a relevant reference for TAPI 1, please let us know.

View Related Products by Product Action

View all ADAM Inhibitors

Keywords: TAPI 1, TAPI 1 supplier, TAPI1, ADAM17, metalloproteases, MMPs, metalloproteinases, inhibits, inhibitors, adams, TNFa, TNFα, converting, enzyme, TACE, ADAMs, Matrix, Metalloprotease, 6162, Tocris Bioscience

Citations for TAPI 1

Citations are publications that use Tocris products.

Currently there are no citations for TAPI 1. Do you know of a great paper that uses TAPI 1 from Tocris? Please let us know.

Reviews for TAPI 1

There are currently no reviews for this product. Be the first to review TAPI 1 and earn rewards!

Have you used TAPI 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Alzheimer's Poster

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.