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UK 383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).
Sold for research purposes under agreement from Pfizer Inc.
UK 383367 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 324.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.83 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the biological activity of the product.
Allan et al (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 36 399 PMID: 16854779
Fish et al (2007) Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 50 3442 PMID: 17591762
Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562 PMID: 18945617
If you know of a relevant reference for UK 383367, please let us know.
Keywords: UK 383367, UK 383367 supplier, pfizer, UK383367, procollagen, c, proteinase, BMP-1, bone, morphogenic, morphogenetic, proteins, inhibitors, inhibits, Matrix, Metalloprotease, 4188, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for UK 383367 include:
Hays et al (2018) Vascular smooth muscle cells direct extracellular dysregulation in aortic stiffening of hypertensive rats. Aging Cell 17 e12748 PMID: 29603864
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