CL 82198 hydrochloride

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Cat.No. 2632 - CL 82198 hydrochloride | C17H23N2O3.HCl | CAS No. 1188890-36-9
Description: Selective inhibitor of MMP-13
Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (4)

Biological Activity

Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.

Compound Libraries

CL 82198 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 338.83
Formula C17H23N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1188890-36-9
PubChem ID 16760373
InChI Key PIOACXKZWXHBRB-UHFFFAOYSA-N
Smiles Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.88 100
DMSO 25.41 75

Preparing Stock Solutions

The following data is based on the product molecular weight 338.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.76 mL 29.51 mL
5 mM 0.59 mL 2.95 mL 5.9 mL
10 mM 0.3 mL 1.48 mL 2.95 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648

Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122

Lisse et al (2016) PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A 113 E2189 PMID: 27035978


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3 Citations for CL 82198 hydrochloride

Citations are publications that use Tocris products. Selected citations for CL 82198 hydrochloride include:

Wang et al (2013) MMP13 is a critical target gene during the progression of osteoarthritis. J Neurosci 15 R5 PMID: 23298463

Lisse et al (2016) PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A 113 E2189 PMID: 27035978

Meierjohann et al (2010) MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9 201 PMID: 20667128


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Literature in this Area

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