CL 82198 hydrochloride

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Cat.No. 2632 - CL 82198 hydrochloride | C17H23N2O3.HCl | CAS No. 1188890-36-9
Description: Selective inhibitor of MMP-13
Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.

Technical Data

M. Wt 338.83
Formula C17H23N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1188890-36-9
PubChem ID 16760373
InChI Key PIOACXKZWXHBRB-UHFFFAOYSA-N
Smiles Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.41 75
water 33.88 100

Preparing Stock Solutions

The following data is based on the product molecular weight 338.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.76 mL 29.51 mL
5 mM 0.59 mL 2.95 mL 5.9 mL
10 mM 0.3 mL 1.48 mL 2.95 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648 PMID:

Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122 PMID:


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1 Citation for CL 82198 hydrochloride

Citations are publications that use Tocris products. Selected citations for CL 82198 hydrochloride include:

Wang et al (2013) MMP13 is a critical target gene during the progression of osteoarthritis. J Neurosci 15 R5 PMID: 23298463


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