TAPI 2

Pricing Availability   Qty
Cat.No. 6013 - TAPI 2 | CAS No. 689284-12-6
Description: ADAM-17 (TACE) and MMP inhibitor
Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.

Technical Data

M. Wt 415.54
Formula C19H37N5O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 689284-12-6
PubChem ID 10093303
InChI Key LMIQCBIEAHJAMZ-RMTCENKZSA-N
Smiles ONC(C[C@@H](CC(C)C)C(N[C@@H](C(C)(C)C)C(N[C@@H](C)C(NCCN)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 5 mg/ml in water and to 5 mg/ml in ethanol

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Moss et al (2007) Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal.Biochem. 366 144 PMID: 17548045

Wang et al (2016) A disintegrin and metalloproteinase domain 17 regulates colorectal cancer stem cells and chemosensitivity via notch1 signaling. Stem Cells Transl.Med. 5 331 PMID: 26744411


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Citations for TAPI 2

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Literature in this Area

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