Bruton's Tyrosine Kinase

Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. BTK is initially activated by membrane localization which is stimulated by the generation of PIP3.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5592 LCB 03-0110 dihydrochloride
Potent BTK inhibitor; also inhibits c-Src, DDR2 and Syk
1300 LFM-A13
Potent, selective BTK inhibitor
5012 PCI 29732
Potent BTK inhibitor
4710 PF 06465469
Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK
1405 (-)-Terreic acid
Selective inhibitor of BTK

Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. BTK is activated firstly by membrane localization stimulated by PIP3 generation, and subsequently, by transphosphorylation of Tyr-551 by Src family kinases.

Activated BTK is involved in the phosphorylation of a number of signaling molecules involved in the PLCγ, JNK and p38 MAPK pathways, leading to Ca2+ mobilization, mRNA stabilization and the induction of NF-κB and AP-1 transcription factors. BTK activity is negatively regulated by a number of proteins including inhibitor of BTK (IBTK), Sab and c-Cbl. Mutations in this enzyme are known in humans and result in the immunological disorder X-linked agammaglobulemia.

Literature for Bruton's Tyrosine Kinase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Bruton's Tyrosine Kinase Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human BTK NM_000061 Q06187
Mouse Btk NM_013482 P35991
Rat Btk NM_001007798 Q5S255