Bruton's Tyrosine Kinase

Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. BTK is initially activated by membrane localization which is stimulated by the generation of PIP3.

Products
Background
Literature
Gene Data

Inhibitors

Cat. No. Product Name / Activity
6813 Ibrutinib
Potent and selective BTK inhibitor
5592 LCB 03-0110 dihydrochloride
Potent BTK inhibitor; also inhibits c-Src, DDR2 and Syk
1300 LFM-A13
Potent, selective BTK inhibitor
5012 PCI 29732
Potent BTK inhibitor
4710 PF 06465469
Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK
1405 (-)-Terreic acid
Selective inhibitor of BTK

Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. BTK is activated firstly by membrane localization stimulated by PIP3 generation, and subsequently, by transphosphorylation of Tyr-551 by Src family kinases.

Activated BTK is involved in the phosphorylation of a number of signaling molecules involved in the PLCγ, JNK and p38 MAPK pathways, leading to Ca2+ mobilization, mRNA stabilization and the induction of NF-κB and AP-1 transcription factors. BTK activity is negatively regulated by a number of proteins including inhibitor of BTK (IBTK), Sab and c-Cbl. Mutations in this enzyme are known in humans and result in the immunological disorder X-linked agammaglobulemia.

External sources of pharmacological information for Bruton's Tyrosine Kinase :

    Literature for Bruton's Tyrosine Kinase

    Tocris offers the following scientific literature for Bruton's Tyrosine Kinase to showcase our products. We invite you to request* or download your copy today!

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    Bruton's Tyrosine Kinase Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human BTK NM_000061 Q06187
    Mouse Btk NM_013482 P35991
    Rat Btk NM_001007798 Q5S255