Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50 values are 31 and 48 nM respectively).
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.62||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 523.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||38.19 mL||190.97 mL||381.95 mL|
|0.25 mM||7.64 mL||38.19 mL||76.39 mL|
|0.5 mM||3.82 mL||19.1 mL||38.19 mL|
|2.5 mM||0.76 mL||3.82 mL||7.64 mL|
References are publications that support the biological activity of the product.
Zapf et al (2012) Covalent inhibitors of interleukin-2 inducible T cell kinase (Itk) with nanomolar potency in a whole-blood assay. J.Med.Chem. 55 10047 PMID: 23098091
If you know of a relevant reference for PF 06465469, please let us know.
View Related Products by Product Action
Keywords: PF 06465469, PF 06465469 supplier, PF06465469, Pfizer, interleukin-2, IL-2, inducible, T, cell, kinase, ITK, inhibitors, inhibits, potent, Brutons, tyrosine, BTK, Tyrosine, Kinase, (BTK), 4710, Tocris Bioscience
Citations for PF 06465469
Citations are publications that use Tocris products.
Currently there are no citations for PF 06465469. Do you know of a great paper that uses PF 06465469 from Tocris? Please let us know.
Reviews for PF 06465469
There are currently no reviews for this product. Be the first to review PF 06465469 and earn rewards!
Have you used PF 06465469?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.