PCI 29732

Pricing Availability   Qty
Cat.No. 5012 - PCI 29732 | C22H21N5O | CAS No. 330786-25-9
Description: Potent BTK inhibitor
Chemical Name: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.

Compound Libraries

PCI 29732 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.44
Formula C22H21N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 330786-25-9
PubChem ID 22347110
InChI Key GMJUPMONHWAZCP-UHFFFAOYSA-N
Smiles NC1=C2C(N(C4CCCC4)N=C2C3=CC=C(OC5=CC=CC=C5)C=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.14 100
ethanol 18.57 50

Preparing Stock Solutions

The following data is based on the product molecular weight 371.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References

References are publications that support the biological activity of the product.

Honigberg et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 107 13075 PMID: 20615965

Krishnamurty et al (2013) Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 9 43 PMID: 23143416


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Keywords: PCI 29732, PCI 29732 supplier, PCI29732, Brutons, Tyrosine, Kinase, (BTK), 5012, Tocris Bioscience

Citations for PCI 29732

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