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Biological Activity for PCI 29732
PCI 29732 is a potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.
Compound Libraries for PCI 29732
Technical Data for PCI 29732
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PCI 29732
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PCI 29732
The following data is based on the product molecular weight 371.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.46 mL||26.92 mL|
|5 mM||0.54 mL||2.69 mL||5.38 mL|
|10 mM||0.27 mL||1.35 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for PCI 29732
References are publications that support the biological activity of the product.
Honigberg et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 107 13075 PMID: 20615965
Krishnamurty et al (2013) Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 9 43 PMID: 23143416
If you know of a relevant reference for PCI 29732, please let us know.
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Keywords: PCI 29732, PCI 29732 supplier, PCI29732, Brutons, Tyrosine, Kinase, (BTK), 5012, Tocris Bioscience
Citations for PCI 29732
Citations are publications that use Tocris products.
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Literature in this Area
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