Cancer Stem Cells

Cancer stem cells (CSCs), also known as tumor initiation cells (TICs), are undifferentiated cancer cells that can self-renew and differentiate into bulk tumor cells. They are thought to have a role in the resistance of tumors to therapy, and for disease recurrence.

Literature (5)
Cat. No. Product Name / Activity
6934 673 A
Depletes CD133+ cancer stem cells (CSC); ALDH1A (aldehyde dehydrogenase) inhibitor
5802 A37
ALDH1A1 inhibitor; disrupts spheroid formation of ovarian cancer cells
6868 8-Azaadenosine
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
6933 CM 10
Depletes CD133+ cancer stem cells; ALDH1A inhibitor
1623 Cyclopamine
Inhibitor of Hedgehog (Hh) signaling; depletes stem-like cancer cells in glioblastoma
1368 Geldanamycin
Selective Hsp90 inhibitor; breast cancer stem cell inhibitor
1803 ITE
Induces stem-like cancer cell differentiation; also inhibits TGF-beta -induced human myofibroblast differentiation
6856 α-Mangostin
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
5727 MC 1742
Induces CSC apoptosis; also stimulates CSC osteogenic differentiation
6429 ML 210
Induces ferroptosis in tumor initiation cells; glutathione peroxidases (GPX4) inhibitor; synthetically lethal HRAS compound
4829 ML 239
Breast cancer stem cell inhibitor
7874 N-Acetylcysteine
Component of organoid culture media for NSCLC and CRC; also GSH precursor and antioxidant
5522 Napabucasin
Blocks cancer stem cell self-renewal; STAT3 inhibitor
4079 Niclosamide
Inhibits AML stem cells; STAT3 and mTORC1 signaling inhibitor
6538 PF 04449913 maleate
Potent Smo antagonist; eliminates self-propagation capacity of AML cells
6957 Reparixin L-lysine salt
CXCR1 and CXCR2 allosteric antagonist; depletes breast cancer stem cells
4189 SC 26196
Selective Δ6 desaturase inhibitor; eliminates cancer stem cells from ovarian cancer cell lines
5207 STF 118804
Depletes leukemia stem cells; NAMPT inhibitor
3070 Thioridazine hydrochloride
Selective inducer of CSC differentiation; anticancer agent
5960 TMI 1
Selectively cytotoxic towards CSCs
5328 TY 52156
Inhibits S1P-induced breast cancer stem cell expansion; S1P3 receptor antagonist
5305 Verteporfin
Suppresses cancer stem cell properties; YAP inhibitor
6111 Zoledronic Acid
Inhibits breast cancer cell renewal via inactivation of NF-κB; also potent FPP synthase inhibitor

Cancer stem cells (CSCs), also known as tumor initiation cells (TICs), are undifferentiated cancer cells that can self-renew and differentiate into bulk tumor cells. They are highly tumorigenic and are thought to be responsible, in some circumstances, for the resistance of tumors to chemo- and radiotherapy, as well as for disease recurrence following treatment. CSCs possess several characteristics that enable them to resist cancer therapies, including a slow cell cycle, resistance to oxidative stress, the ability to rapidly repair DNA damage and the capacity to expel anticancer drugs.

The origin of CSCs is unclear; they may derive from normal stem or progenitor cells or other cancer cells. Self-renewal of CSCs is through asymmetric division, by which one daughter cell retains the ability to self-renew, while the other will differentiate. CSC self-renewal and maintenance are regulated by various signaling pathways, including Notch, Hedgehog and Wnt, and these pathways are potential targets for new cancer therapies aimed at the elimination of CSCs and the prevention of relapse.

Literature for Cancer Stem Cells

Tocris offers the following scientific literature for Cancer Stem Cells to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics in Cancer Research Product Guide

Epigenetics in Cancer Research Product Guide

This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:

  • Histone Methylation
  • Histone Acetylation
  • DNA Methylation
  • Ubiquitination
  • Bromodomains
Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.