Aldehyde Dehydrogenases

Aldehyde dehydrogenase enzymes oxidize aldehydes to generate carboxylic acids for use in the muscle and heart. Numerous aldehyde dehydrogenase genes exist, of which ALDH2 is best known for its role in alcohol oxidation.

Products
Background
Literature
Gene Data

Inhibitors

Cat. No. Product Name / Activity
6934 673 A
ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
5802 A37
ALDH1A1 inhibitor
6933 CM 10
ALDH1A inhibitor; depletes CD133+ cancer stem cells
5164 CVT 10216
Potent and selective ALDH2 inhibitor
3807 Disulfiram
Aldehyde dehydrogenase inhibitor; displays a range of other activities
5934 NCT 501 hydrochloride
Potent and selective ALDH1A1 inhibitor
4736 WIN 18446
ALDH1A2 inhibitor

Activators

Cat. No. Product Name / Activity
4005 Alda 1
ALDH2 activator; cardioprotective

Related Targets

    Aldehyde dehydrogenase enzymes oxidize aldehydes to generate carboxylic acids for use in the muscle and heart. Numerous aldehyde dehydrogenase genes exist, of which ALDH2 is best known for its role in alcohol oxidation.

    Over 550 aldehyde genes have been identified across different species, which can be split into numerous families. There are 19 known human aldehyde dehydrogenase genes. ALDH2, a human mitochondrial enzyme belonging to family 2, is responsible for breaking down acetaldehyde produced by ethanol. Inhibition of aldehyde dehydrogenase therefore results in the build-up of acetaldehyde, a toxic metabolite which is thought to be responsible for 'hangover' symptoms.

    External sources of pharmacological information for Aldehyde Dehydrogenases :

      Literature for Aldehyde Dehydrogenases

      Tocris offers the following scientific literature for Aldehyde Dehydrogenases to showcase our products. We invite you to request* or download your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.


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      Aldehyde Dehydrogenase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      ALDH1A1 Human ALDH1A1 NM_000689 P00352
      Mouse Aldh1a1 NM_013467 P24549
      Rat Aldh1a1 NM_022407 P51647
      ALDH1A2 Human ALDH1A2 NM_001206897 O94788
      Mouse Aldh1a2 NM_009022 Q62148
      Rat Aldh1a2 NM_053896 Q63639
      ALDH1A3 Human ALDH1A3 NM_00693 P47895
      Mouse Aldh1a3 NM_053080 Q9JHW9
      Rat Aldh1a3 NM_153300 Q8K4D8
      ALDH1B1 Human ALDH1B1 NM_000692 P30837
      Mouse Aldh1b1 NM_028270 B1AWX7
      Rat Aldh1b1 NM_001011975 AAH81884
      ALDH1L1 Human ALDH1L1 NM_012190 O75891
      Mouse Aldh1l1 NM_027406 Q8R0Y6
      Rat Aldh1l1 NM_022547 P28037
      ALDH1L2 Human ALDH1L2 NM_001034173 Q3SY69
      Mouse Aldh1l2 NM_153543 E9QLV8
      Rat Aldh1l2 NM_001191778
      ALDH2 Human ALDH2 NM_000690 P05091
      Mouse Aldh2 NM_009656
      Rat Aldh2 NM_032416 Q2QAI2
      ALDH3A1 Human ALDH3A1 NM_000691 P30838
      Mouse Aldh3a1 Q3UNF5
      Rat Aldh3a1 NM_031972 P11883
      ALDH3A2 Human ALDH3A2 NM_000382 P51648
      Mouse Aldh3a2 NM_007437 B1ATI0
      Rat Aldh3a2 NM_031731 P30839
      ALDH3B1 Human ALDH3B1 NM_000694 P43353
      Mouse Aldh3b1 NM_026316 Q80VQ0
      Rat Aldh3b1 NM_001006998 Q5XI42
      ALDH3B2 Human ALDH3B2 NM_000695 P48448
      Mouse Aldh3b2 NM_001177438
      ALDH4A1 Human ALDH4A1 NM_001161504 P30038
      Mouse Aldh4a1 NM_175438 B1AXW8
      Rat Aldh4a1 NM_001134698
      ALDH5A1 Human ALDH5A1 NM_170740 P51649
      Mouse Aldh5a1 NM_172532 Q8BWF0
      ALD6A1 Human ALDH6A1 NM_005589 Q02252
      Mouse Aldh6a1 NM_134042 Q9EQ20
      Rat Aldh6a1 NM_031057 Q2QAI2
      ALDH8A1 Human ALDH8A1 NM_001193480 Q9H2A2
      Mouse Aldh8a1 NM_178713 Q8BH00
      Rat Aldh8a1 NM_001191088 NP_001178017
      ALD9A1 Human ALDH9A1 NM_000696 p49189
      Mouse Aldh9a1 NM_019993 Q9JLJ2
      Rat Aldh9a1 NM_022273 Q9JLJ3
      ALDH16A1 Human ALDH16A1 NM_001145396 Q8IZ83
      Mouse Aldh16a1 NM_145954 Q571I9
      Rat Aldh16a1 NM_001033706 Q3T1L0
      ALDH18A1 Human ALDH18A1 NM_001108524 P54886
      Rat Aldh18a1 NM_001191088