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Description: Endogenous agonist for the transcription factor aryl hydrocarbon receptor
Alternative Names: Aryl hydrocarbon receptor ligand
Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
Purity: ≥98% (HPLC)
Citations (9)

Biological Activity for ITE

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Compound Libraries for ITE

ITE is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for ITE

M. Wt 286.3
Formula C14H10N2O3S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 448906-42-1
PubChem ID 4668801
Smiles COC(=O)C1=CSC(=N1)C(=O)C1=CNC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ITE

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.63 100

Preparing Stock Solutions for ITE

The following data is based on the product molecular weight 286.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.93 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets for ITE

Certificate of Analysis / Product Datasheet
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References for ITE

References are publications that support the biological activity of the product.

Song et al (2002) A ligand for the aryl hydrocarbon receptor isolated from lung. Proc.Natl.Acad.Sci.U.S.A. 99 14694 PMID: 12409613

Lehmann et al (2011) The aryl hydrocarbon receptor ligand ITE inhibits TGF beta 1-induced human myofibroblast differentiation. Am.J.Pathol. 178 1556 PMID: 21406171

Cheng et al (2015) Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat.Commun. 6 7209 PMID: 26059097

Wang et al (2013) An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 340 63 PMID: 23851185

If you know of a relevant reference for ITE, please let us know.

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9 Citations for ITE

Citations are publications that use Tocris products. Selected citations for ITE include:

Wu et al (2014) ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR. PLoS One 9 e86549 PMID: 24475139

Wang et al (2013) An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett 340 63 PMID: 23851185

Fusco et al (2017) HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Front Microbiol 8 240 PMID: 28265266

Boule (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep 8 1826 PMID: 29379138

Do you know of a great paper that uses ITE from Tocris? Please let us know.

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