Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Description: Endogenous agonist for the transcription factor aryl hydrocarbon receptor
Alternative Names: Aryl hydrocarbon receptor ligand
Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
Purity: ≥98% (HPLC)
Citations (9)
Literature (1)

Biological Activity for ITE

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Licensing Information

Sold under license, US Patent Application 2002183524

Compound Libraries for ITE

ITE is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for ITE

M. Wt 286.3
Formula C14H10N2O3S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 448906-42-1
PubChem ID 4668801
Smiles COC(=O)C1=CSC(=N1)C(=O)C1=CNC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ITE

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.63 100

Preparing Stock Solutions for ITE

The following data is based on the product molecular weight 286.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.93 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for ITE

Certificate of Analysis / Product Datasheet
Select another batch:

References for ITE

References are publications that support the biological activity of the product.

Song et al (2002) A ligand for the aryl hydrocarbon receptor isolated from lung. Proc.Natl.Acad.Sci.U.S.A. 99 14694 PMID: 12409613

Lehmann et al (2011) The aryl hydrocarbon receptor ligand ITE inhibits TGF beta 1-induced human myofibroblast differentiation. Am.J.Pathol. 178 1556 PMID: 21406171

Cheng et al (2015) Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat.Commun. 6 7209 PMID: 26059097

Wang et al (2013) An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 340 63 PMID: 23851185

If you know of a relevant reference for ITE, please let us know.

View Related Products by Product Action

View all Aryl Hydrocarbon Receptor Agonists

Keywords: ITE, ITE supplier, Endogenous, agonists, transcription, factor, aryl, hydrocarbon, receptor, AHR, Receptors, myofibroblast, differentiation, inhibits, inhibitors, stem, cells, stem-like, cancer, Aryl, ligand, Hydrocarbon, Cancer, Stem, Cells, Cell, Differentiation, 1803, Tocris Bioscience

9 Citations for ITE

Citations are publications that use Tocris products. Selected citations for ITE include:

Wang et al (2014) Decreased expression of the aryl hydrocarbon receptor in ocular Behcet's disease. Mediators Inflamm 2014 195094 PMID: 25045206

Yeste et al (2012) Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 109 11270 PMID: 22745170

Baker et al (2018) Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers. Mol Carcinog 57 606 PMID: 29323757

Wu et al (2014) ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR. PLoS One 9 e86549 PMID: 24475139

Do you know of a great paper that uses ITE from Tocris? Please let us know.

Reviews for ITE

There are currently no reviews for this product. Be the first to review ITE and earn rewards!

Have you used ITE?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors