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Napabucasin is a STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.
Napabucasin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 240.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||20.82 mL||104.08 mL||208.15 mL|
|1 mM||4.16 mL||20.82 mL||41.63 mL|
|2 mM||2.08 mL||10.41 mL||20.82 mL|
|10 mM||0.42 mL||2.08 mL||4.16 mL|
References are publications that support the biological activity of the product.
Li et al (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 112 1839 PMID: 25605917
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Keywords: Napabucasin, Napabucasin supplier, Stat3, inhibitors, inhibits, cancer, stem, cell, stemness, high, self-renewal, spherogenesis, metastasis, STAT, Stem, Cell, Signaling, Cancer, Cells, 5522, Tocris Bioscience
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