Napabucasin

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Description: STAT3 inhibitor; also blocks cancer stem cell self-renewal
Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)

Biological Activity for Napabucasin

Napabucasin is a STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

Compound Libraries for Napabucasin

Napabucasin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Napabucasin

M. Wt 240.21
Formula C14H8O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 83280-65-3
PubChem ID 10331844
InChI Key DPHUWDIXHNQOSY-UHFFFAOYSA-N
Smiles O=C(C1=C2C=C(C(C)=O)O1)C3=CC=CC=C3C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Napabucasin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.8 20

Preparing Stock Solutions for Napabucasin

The following data is based on the product molecular weight 240.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 20.82 mL 104.08 mL 208.15 mL
1 mM 4.16 mL 20.82 mL 41.63 mL
2 mM 2.08 mL 10.41 mL 20.82 mL
10 mM 0.42 mL 2.08 mL 4.16 mL

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References for Napabucasin

References are publications that support the biological activity of the product.

Li et al (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 112 1839 PMID: 25605917


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Keywords: Napabucasin, Napabucasin supplier, Stat3, inhibitors, inhibits, cancer, stem, cell, stemness, high, self-renewal, spherogenesis, metastasis, STAT, Stem, Cell, Signaling, Cancer, Cells, 5522, Tocris Bioscience

Citations for Napabucasin

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Pathways for Napabucasin

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.