Napabucasin

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Cat.No. 5522 - Napabucasin | C14H8O4 | CAS No. 83280-65-3
Description: STAT3 inhibitor; also blocks cancer stem cell self-renewal
Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

Compound Libraries

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Technical Data

M. Wt 240.21
Formula C14H8O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 83280-65-3
PubChem ID 10331844
InChI Key DPHUWDIXHNQOSY-UHFFFAOYSA-N
Smiles O=C(C1=C2C=C(C(C)=O)O1)C3=CC=CC=C3C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.8 20

Preparing Stock Solutions

The following data is based on the product molecular weight 240.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 20.82 mL 104.08 mL 208.15 mL
1 mM 4.16 mL 20.82 mL 41.63 mL
2 mM 2.08 mL 10.41 mL 20.82 mL
10 mM 0.42 mL 2.08 mL 4.16 mL

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References

References are publications that support the biological activity of the product.

Li et al (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 112 1839 PMID: 25605917


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Citations for Napabucasin

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Napabucasin

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.