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Selective fatty acid desaturase 2 (FADS2, also known as Δ6 desaturase) inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ5 desaturase and SCD-1/Δ9 desaturase, respectively) (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 423.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||9.44 mL||47.22 mL||94.44 mL|
|1.25 mM||1.89 mL||9.44 mL||18.89 mL|
|2.5 mM||0.94 mL||4.72 mL||9.44 mL|
|12.5 mM||0.19 mL||0.94 mL||1.89 mL|
References are publications that support the biological activity of the product.
Obukowicz et al (1998) Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 287 157 PMID: 9765335
Hansen-Petrik et al (2002) Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 175 157 PMID: 11741743
Zhang et al (2010) A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 15 169 PMID: 20086206
Li et al (2017) Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells. Cell Stem Cell 20 1
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Keywords: SC 26196, SC 26196 supplier, Pfizer, SC26196, desaturases, delta6, d6, Δ6, selective, inhibitors, inhibits, anti-inflammatory, fatty, acid, metabolism, Other, Lipid, Metabolism, Cancer, Stem, Cells, Oxygenases/Oxidases, 4189, Tocris Bioscience
1 Citation for SC 26196
Citations are publications that use Tocris products. Selected citations for SC 26196 include:
Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. PLoS One 12 109 PMID: 26656090
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