Selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 423.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.36 mL||11.8 mL||23.61 mL|
|5 mM||0.47 mL||2.36 mL||4.72 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Obukowicz et al (1998) Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 287 157 PMID: 9765335
Hansen-Petrik et al (2002) Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 175 157 PMID: 11741743
Zhang et al (2010) A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 15 169 PMID: 20086206
If you know of a relevant reference for SC 26196, please let us know.
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Keywords: SC 26196, supplier, Pfizer, SC26196, desaturases, delta6, d6, Δ6, selective, inhibitors, inhibits, anti-inflammatory, fatty, acid, metabolism, Other, Lipid, Metabolism, Cancer, Stem, Cells, Other, Lipid, Metabolism, Tocris Bioscience
1 Citation for SC 26196
Citations are publications that use Tocris products. Selected citations for SC 26196 include:
Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. PLoS One 12 109 PMID: 26656090
Do you know of a great paper that uses SC 26196 from Tocris? If so please let us know.
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