SC 26196

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Cat.No. 4189 - SC 26196 | C27H29N5 | CAS No. 218136-59-5
Description: Selective Δ6 desaturase inhibitor
Chemical Name: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 423.55
Formula C27H29N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 218136-59-5
PubChem ID 9845201
Smiles N#CC(C3=CC=CC=C3)(C4=CC=CC=C4)CCCN1CCN(/N=C/C2=CN=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 423.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.8 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References are publications that support the products' biological activity.

Obukowicz et al (1998) Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 287 157 PMID: 9765335

Hansen-Petrik et al (2002) Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 175 157 PMID: 11741743

Zhang et al (2010) A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 15 169 PMID: 20086206

Li et al (2017) Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells. Cell Stem Cell 0 1 PMID:

If you know of a relevant reference for SC 26196, please let us know.

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1 Citation for SC 26196

Citations are publications that use Tocris products. Selected citations for SC 26196 include:

Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. PLoS One 12 109 PMID: 26656090

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