YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 718.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.39 mL||6.96 mL||13.91 mL|
|5 mM||0.28 mL||1.39 mL||2.78 mL|
|10 mM||0.14 mL||0.7 mL||1.39 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
References are publications that support the products' biological activity.
Liu-Chittenden et al (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26 1300 PMID: 22677547
Brodowska et al (2014) The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 124 67 PMID: 24837142
Song et al (2014) Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 74 4170 PMID: 24906622
If you know of a relevant reference for Verteporfin, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Verteporfin, supplier, YAP, yes, associated, protein, hippo, inhibits, inhibitors, TEAD, Visudyne, Cancer, Stem, Cells, Hippo/Yap, signaling, Hippo/Yap, signaling, Tocris Bioscience
Citations for Verteporfin
Citations are publications that use Tocris products.
Currently there are no citations for Verteporfin. Do you know of a great paper that uses Verteporfin from Tocris? If so please let us know.
Reviews for Verteporfin
Average Rating: 5 (Based on 1 Review)
Have you used Verteporfin?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Used it in in vitro treatment assays at concentration of 1 to 10microM for 72 hours. The treatment resulted in a significant time- and dose-dependent inhibition of cell growth & viability.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.