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YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 718.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||6.96 mL||34.78 mL||69.56 mL|
|1 mM||1.39 mL||6.96 mL||13.91 mL|
|2 mM||0.7 mL||3.48 mL||6.96 mL|
|10 mM||0.14 mL||0.7 mL||1.39 mL|
References are publications that support the biological activity of the product.
Liu-Chittenden et al (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26 1300 PMID: 22677547
Brodowska et al (2014) The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 124 67 PMID: 24837142
Song et al (2014) Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 74 4170 PMID: 24906622
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Keywords: Verteporfin, Verteporfin supplier, YAP, yes, associated, protein, hippo, inhibits, inhibitors, TEAD, Visudyne, Cancer, Stem, Cells, Hippo/Yap, signaling, 5305, Tocris Bioscience
7 Citations for Verteporfin
Citations are publications that use Tocris products. Selected citations for Verteporfin include:
Yosefzon et al (2018) Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell 70 573 PMID: 29775577
Li et al (2019) Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell 179 687 PMID: 31626770
Kato et al (2018) Pulmonary pericytes regulate lung morphogenesis. Nat Commun 9 2448 PMID: 29934496
An et al (2018) Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. Cell Rep 25 702 PMID: 30332649
Fisher et al (2017) Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells. Oncotarget 8 110257 PMID: 29299145
Seong et al (2017) A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res 77 696 PMID: 27899382
Eales (2018) Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species. Sci Rep 8 14358 PMID: 30254296
Do you know of a great paper that uses Verteporfin from Tocris? Please let us know.
Reviews for Verteporfin
Average Rating: 5 (Based on 2 Reviews.)
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Used it in in vitro treatment assays at concentration of 1 to 10microM for 72 hours. The treatment resulted in a significant time- and dose-dependent inhibition of cell growth & viability.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.