Pricing Availability   Qty
Description: YAP inhibitor
Alternative Names: Visudyne
Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Purity: ≥95% (HPLC)
Citations (14)
Reviews (2)
Literature (3)
Pathways (1)

Biological Activity for Verteporfin

Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Technical Data for Verteporfin

M. Wt 718.79
Formula C41H42N4O8
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 129497-78-5
PubChem ID 5362420
Smiles CC(C(/C=C1N/C([C@@]2(C)C\1=CC=C(C(OC)=O)[C@H]2C(OC)=O)=C\C3=N/C(C(CCC(O)=O)=C3C)=C\4)=N/5)=C(C=C)C5=C\C6=C(C)C(CCC(OC)=O)=C4N6.CC(C(/C=C7N/C([C@@]8(C)C\7=CC=C(C(OC)=O)[C@H]8C(OC)=O)=C\C9=N/C(C(CCC(OC)=O)=C9C)=C\%10)=N/%11)=C(C=C)C%11=C\C%12=C(C)C(CCC(O)=O)=C%10N%12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Verteporfin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.38 20

Preparing Stock Solutions for Verteporfin

The following data is based on the product molecular weight 718.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.96 mL 34.78 mL 69.56 mL
1 mM 1.39 mL 6.96 mL 13.91 mL
2 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.14 mL 0.7 mL 1.39 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Product Datasheets for Verteporfin

Certificate of Analysis / Product Datasheet
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References for Verteporfin

References are publications that support the biological activity of the product.

Liu-Chittenden et al (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26 1300 PMID: 22677547

Brodowska et al (2014) The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 124 67 PMID: 24837142

Song et al (2014) Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 74 4170 PMID: 24906622

If you know of a relevant reference for Verteporfin, please let us know.

View Related Products by Product Action

View all Hippo and YAP/TAZ Signaling Inhibitors

Keywords: Verteporfin, Verteporfin supplier, YAP, yes, associated, protein, hippo, inhibits, inhibitors, TEAD, Visudyne, Cancer, Stem, Cells, Hippo/Yap, signaling, 5305, Tocris Bioscience

14 Citations for Verteporfin

Citations are publications that use Tocris products. Selected citations for Verteporfin include:

Jun et al (2019) Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer. Clin Cancer Res 25 1070-1086 PMID: 30397177

Jose P et al (2019) A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells. Mol Cancer Res 17 1735-1747 PMID: 31076498

Bo et al (2020) Derivation of trophoblast stem cells from naïve human pluripotent stem cells. Elife 9 PMID: 32048992

Fisher et al (2017) Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells. Oncotarget 8 110257 PMID: 29299145

Do you know of a great paper that uses Verteporfin from Tocris? Please let us know.

Reviews for Verteporfin

Average Rating: 5 (Based on 2 Reviews.)

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Generation of EPS-blastoids.
By Anonymous on 02/27/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: EPS


PMID: 31626770
review image

In vitro cell treatment using Verteporfin.
By Sara Piccirillo on 01/16/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: cancer cell lines

Used it in in vitro treatment assays at concentration of 1 to 10microM for 72 hours. The treatment resulted in a significant time- and dose-dependent inhibition of cell growth & viability.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for Verteporfin

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
Notch Signaling Pathway

Notch Signaling Pathway

The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signaling can cause developmental defects and a range of adult pathologies.
Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.