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Cat.No. 5305 - Verteporfin | C41H42N4O8 | CAS No. 129497-78-5
Description: YAP inhibitor; disrupts YAP-TEAD interactions
Alternative Names: Visudyne
Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Purity: ≥97% (HPLC)

Biological Activity

YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Technical Data

M. Wt 718.79
Formula C41H42N4O8
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 129497-78-5
PubChem ID 5362420
Smiles CC(C(/C=C4\N/C([C@@]5(C)C4=CC=C(C(OC)=O)[C@H]5[C@](OC)=O)=C\C6=N\C(C(CCC(OC)=O)=C6C)=C3)=N2)=C(C=C)/C2=C/C1=C(C)C(CCC(O)=O)=C/3N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.38 20

Preparing Stock Solutions

The following data is based on the product molecular weight 718.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.96 mL 13.91 mL
5 mM 0.28 mL 1.39 mL 2.78 mL
10 mM 0.14 mL 0.7 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Liu-Chittenden et al (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26 1300 PMID: 22677547

Brodowska et al (2014) The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 124 67 PMID: 24837142

Song et al (2014) Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 74 4170 PMID: 24906622

If you know of a relevant reference for Verteporfin, please let us know.

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Citations for Verteporfin

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Signal Transduction
  • Stem Cells

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