Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 407.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.46 mL||12.28 mL||24.57 mL|
|5 mM||0.49 mL||2.46 mL||4.91 mL|
|10 mM||0.25 mL||1.23 mL||2.46 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References are publications that support the products' biological activity.
Sachlos et al (2012) Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print PMID: 22632761
Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print PMID: 22460505
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Keywords: Thioridazine hydrochloride, supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Non-selective, Dopamine, Cancer, Stem, Cells, Cancer, Stem, Cell, Differentiation, Non-selective, Dopamine, Tocris Bioscience
1 Citation for Thioridazine hydrochloride
Citations are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:
Chigaev et al (2011) Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem 286 5455 PMID: 21131351
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