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Biological Activity for Thioridazine hydrochloride
Thioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.
Technical Data for Thioridazine hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Thioridazine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Thioridazine hydrochloride
The following data is based on the product molecular weight 407.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.46 mL||12.28 mL||24.57 mL|
|5 mM||0.49 mL||2.46 mL||4.91 mL|
|10 mM||0.25 mL||1.23 mL||2.46 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
Product Datasheets for Thioridazine hydrochloride
References for Thioridazine hydrochloride
References are publications that support the biological activity of the product.
Merck Index 13 9435
Sachlos et al (2012) Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print PMID: 22632761
Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print PMID: 22460505
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Keywords: Thioridazine hydrochloride, Thioridazine hydrochloride supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Non-selective, Cancer, Stem, Cells, Cell, Differentiation, 3070, Tocris Bioscience
1 Citation for Thioridazine hydrochloride
Citations are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:
Chigaev et al (2011) Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem 286 5455 PMID: 21131351
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.