Thioridazine hydrochloride

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Cat.No. 3070 - Thioridazine hydrochloride | C21H26N2S2.HCl | CAS No. 130-61-0
Description: Dopamine receptor antagonist; antipsychotic
Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.

Compound Libraries

Thioridazine hydrochloride is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 407.04
Formula C21H26N2S2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 130-61-0
PubChem ID 66062
InChI Key NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Smiles CN(CCCC4)C4CCN2C3=C(C=CC(SC)=C3)SC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.7 100
ethanol 20.35 50
water 30.53 75

Preparing Stock Solutions

The following data is based on the product molecular weight 407.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.28 mL 24.57 mL
5 mM 0.49 mL 2.46 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Merck Index 13 9435 PMID:

Sachlos et al (2012) Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print PMID: 22632761

Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print PMID: 22460505


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View all Non-selective Dopamine Antagonists

Keywords: Thioridazine hydrochloride, supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Non-selective, Dopamine, Cancer, Stem, Cells, Cancer, Stem, Cell, Differentiation, Non-selective, Dopamine, Tocris Bioscience

1 Citation for Thioridazine hydrochloride

Citations are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:

Chigaev et al (2011) Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem 286 5455 PMID: 21131351


Do you know of a great paper that uses Thioridazine hydrochloride from Tocris? If so please let us know.

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