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A37 is an ALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.
A37 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 431.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.32 mL||11.59 mL||23.17 mL|
|5 mM||0.46 mL||2.32 mL||4.63 mL|
|10 mM||0.23 mL||1.16 mL||2.32 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the biological activity of the product.
Morgan and Hurley (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 58 1964 PMID: 25634381
Condello et al (2015) β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34 2297 PMID: 24954508
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Keywords: A37, A37 supplier, Aldehyde, dehydrogenase-1A1, ALDH1A1, inhibitors, inhibits, CM037, CM, 037, Dehydrogenase, Cancer, Stem, Cells, 5802, Tocris Bioscience
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