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Description: ALDH1A1 inhibitor
Alternative Names: CM 037
Chemical Name: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
Purity: ≥97% (HPLC)
Citations (1)

Biological Activity for A37

A37 is an ALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.

Compound Libraries for A37

A37 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A37

M. Wt 431.57
Formula C21H25N3O3S2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 896795-60-1
PubChem ID 5049161

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A37

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.16 100
ethanol 43.16 100

Preparing Stock Solutions for A37

The following data is based on the product molecular weight 431.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.17 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for A37

References are publications that support the biological activity of the product.

Morgan and Hurley (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 58 1964 PMID: 25634381

Condello et al (2015) β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34 2297 PMID: 24954508

If you know of a relevant reference for A37, please let us know.

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Keywords: A37, A37 supplier, Aldehyde, dehydrogenase-1A1, ALDH1A1, inhibitors, inhibits, CM037, CM, 037, Dehydrogenase, Cancer, Stem, Cells, 5802, Tocris Bioscience

1 Citation for A37

Citations are publications that use Tocris products. Selected citations for A37 include:

Rui et al (2020) Phenotypic landscape of intestinal organoid regeneration. Nature 586 275-280 PMID: 33029001

Do you know of a great paper that uses A37 from Tocris? Please let us know.

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