A37

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Cat.No. 5802 - A37 | C21H25N3O3S2 | CAS No. 896795-60-1
Description: ALDH1A1 inhibitor
Alternative Names: CM 037
Chemical Name: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

ALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.

Technical Data

M. Wt 431.57
Formula C21H25N3O3S2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 896795-60-1
PubChem ID 5049161
InChI Key SKDRHRAYBYQVNU-UHFFFAOYSA-N
Smiles O=C1N(CCCN2CCCC2)C(SCC(OCC)=O)=NC3=C1SC4=C3C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.16 100
ethanol 43.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 431.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.17 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Morgan and Hurley (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 58 1964 PMID: 25634381

Condello et al (2015) β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34 2297 PMID: 24954508


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Keywords: A37, A37 supplier, Aldehyde, dehydrogenase-1A1, ALDH1A1, inhibitors, inhibits, CM037, CM, 037, Dehydrogenase, Cancer, Stem, Cells, 5802, Tocris Bioscience

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