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PF 04449913 maleate
Biological Activity for PF 04449913 maleate
PF 04449913 maleate is a potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for PF 04449913 maleate
Technical Data for PF 04449913 maleate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 04449913 maleate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PF 04449913 maleate
The following data is based on the product molecular weight 490.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.04 mL||10.19 mL||20.39 mL|
|5 mM||0.41 mL||2.04 mL||4.08 mL|
|10 mM||0.2 mL||1.02 mL||2.04 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
Product Datasheets for PF 04449913 maleate
References for PF 04449913 maleate
References are publications that support the biological activity of the product.
Munchhof et al (2011) Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med.Chem.Lett. 3 106 PMID: 24900436
Fukushima et al (2016) Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 107 1422 PMID: 27461445
Giordani et al (2016) The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells. Oncotarget 7 55313 PMID: 27486815
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Citations for PF 04449913 maleate
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