β-catenin
β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3.
β-catenin Modulators |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 6961 | FzM1.8 |
| Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness | |
Other |
|
| Cat. No. | Product Name / Activity |
| 1626 | Calphostin C |
| Antagonist of the Tcf/β-catenin complex. Also PKC inhibitor | |
| 4344 | FH 535 |
| Inhibitor of Wnt/β-catenin signaling | |
| 4505 | ICG 001 |
| Inhibits TCF/β-catenin-mediated transcription | |
| 4299 | iCRT 14 |
| Inhibits β-catenin-responsive transcription (CRT) | |
| 5214 | IWP 4 |
| Potent inhibitor of Wnt/β-catenin signaling | |
| 3532 | endo-IWR 1 |
| Wnt/β-catenin signaling inhibitor; axin stabilizer | |
| 4651 | JW 67 |
| Wnt pathway inhibitor; induces degradation of active β-catenin | |
| 5653 | JW 74 |
| Wnt pathway inhibitor; induces degradation of active β-catenin | |
| 7002 | KYA 1797K |
| Wnt/β-catenin signaling inhibitor | |
| 6531 | NLS-StAx-h |
| Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions | |
| 3534 | PNU 74654 |
| β-catenin binder; inhibits Wnt signaling | |
| 4254 | TAK 715 |
| Inhibitor of Wnt/β-catenin signaling | |
| 4767 | WAY 316606 hydrochloride |
| Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling | |
| 7580 | WIC1 |
| Inhibitor of Wnt/β-catenin signaling | |
| 3748 | XAV 939 |
| Stimulates β-catenin degradation; inhibits Wnt signaling | |
| 7298 | xStAx-VHLL |
| Selective peptide-based β-catenin Degrader | |
β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3, adenomatous polyposis coli (APC) and axin. Accumulation of β-catenin in the cell cytoplasm prompts its translocation to the nucleus, where it interacts with members of the TCF/LEF family of transcription factors and induces the transcription of Wnt target genes.
This canonical pathway has been shown to influence developmental processes such as cell proliferation and body axis specification, as well as carcinogenesis. Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. β-catenin also plays an essential role in cell-cell adhesion, and is thought to maintain the attachment of stem cells to their niche by interacting with membrane-bound cadherin and α-catenin.
Literature for β-catenin
Tocris offers the following scientific literature for β-catenin to showcase our products. We invite you to request* your copy today!
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Pathways for β-catenin
Wnt Signaling Pathway
The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.
Our Cancer Research Guide highlights over 750 products for cancer research.
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