β-catenin

β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3.

Products
Background
Literature
Pathways
Gene Data
Cat No Product Name / Activity
1626 Calphostin C
Antagonist of the Tcf/β-catenin complex. Also PKC inhibitor
4475 Cardionogen 1
Inhibitor of Wnt/β-catenin signaling
4675 CCT 031374 hydrobromide
Inhibits TCF-dependent transcription; lowers β-catenin levels
4344 FH 535
Inhibitor of Wnt/β-catenin signaling
4505 ICG 001
Inhibits TCF/β-catenin-mediated transcription
4299 iCRT 14
Inhibits β-catenin-responsive transcription (CRT)
5214 IWP 4
Potent inhibitor of Wnt/β-catenin signaling
3532 endo-IWR 1
Wnt/β-catenin signaling inhibitor; axin stabilizer
3947 exo-IWR 1
Negative control for endo-IWR 1 (Cat. No. 3532)
4651 JW 67
Wnt pathway inhibitor; induces degradation of active β-catenin
5653 JW 74
Wnt pathway inhibitor; induces degradation of active β-catenin
3534 PNU 74654
β-catenin binder; inhibits Wnt signaling
4254 TAK 715
Inhibitor of Wnt/β-catenin signaling
4767 WAY 316606 hydrochloride
Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
3748 XAV 939
Stimulates β-catenin degradation; inhibits Wnt signaling

β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3, adenomatous polyposis coli (APC) and axin. Accumulation of β-catenin in the cell cytoplasm prompts its translocation to the nucleus, where it interacts with members of the TCF/LEF family of transcription factors and induces the transcription of Wnt target genes.

This canonical pathway has been shown to influence developmental processes such as cell proliferation and body axis specification, as well as carcinogenesis. Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. β-catenin also plays an essential role in cell-cell adhesion, and is thought to maintain the attachment of stem cells to their niche by interacting with membrane-bound cadherin and α-catenin.

Literature for β-catenin

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for β-catenin

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.

β-catenin Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
β-catenin Human CTNNB1 NM_001098210 X87838
Mouse Ctnnb1 NM_007614 Q02248
Rat Ctnnb1 NM_053357 Q9WU82