WAY 316606 hydrochloride
Secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.
We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 from Tocris is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 484.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.31 mL||51.55 mL||103.11 mL|
|1 mM||2.06 mL||10.31 mL||20.62 mL|
|2 mM||1.03 mL||5.16 mL||10.31 mL|
|10 mM||0.21 mL||1.03 mL||2.06 mL|
References are publications that support the biological activity of the product.
Moore et al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190 PMID: 19932972
Moore et al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105 PMID: 19072540
Bodine et al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063 PMID: 19254787
If you know of a relevant reference for WAY 316606 hydrochloride, please let us know.
Keywords: WAY 316606 hydrochloride, WAY 316606 hydrochloride supplier, WAY316606, hydrochloride, CAS, [915759-45-4], Bone, osteoporosis, secreted, frizzled-related, protein-1, sFRP-1, inhibitors, inhibits, Wnt, signaling, signalling, Beta-catenin, 4767, Tocris Bioscience
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Literature in this Area
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