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WAY 316606 hydrochloride
Biological Activity for WAY 316606 hydrochloride
WAY 316606 hydrochloride is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.
We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 from Tocris is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.
Compound Libraries for WAY 316606 hydrochloride
Technical Data for WAY 316606 hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WAY 316606 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for WAY 316606 hydrochloride
The following data is based on the product molecular weight 484.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.31 mL||51.55 mL||103.11 mL|
|1 mM||2.06 mL||10.31 mL||20.62 mL|
|2 mM||1.03 mL||5.16 mL||10.31 mL|
|10 mM||0.21 mL||1.03 mL||2.06 mL|
Product Datasheets for WAY 316606 hydrochloride
References for WAY 316606 hydrochloride
References are publications that support the biological activity of the product.
Moore et al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190 PMID: 19932972
Moore et al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105 PMID: 19072540
Bodine et al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063 PMID: 19254787
If you know of a relevant reference for WAY 316606 hydrochloride, please let us know.
Keywords: WAY 316606 hydrochloride, WAY 316606 hydrochloride supplier, WAY316606, hydrochloride, CAS, [915759-45-4], Bone, osteoporosis, secreted, frizzled-related, protein-1, sFRP-1, inhibitors, inhibits, Wnt, signaling, signalling, Beta-catenin, 4767, Tocris Bioscience
1 Citation for WAY 316606 hydrochloride
Citations are publications that use Tocris products. Selected citations for WAY 316606 hydrochloride include:
Ichijo et al (2017) Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun 8 508 PMID: 28894084
Do you know of a great paper that uses WAY 316606 hydrochloride from Tocris? Please let us know.
Reviews for WAY 316606 hydrochloride
Average Rating: 5 (Based on 1 Review.)
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We are a reference lab and needed to compare a questioned product to authentic WAY-316606. We generated our own purity and identity information on this product and confirmed the COA. The attached PDF shows that the infrared spectrum was an exact match with the questioned material. That's exactly what we needed to confirm.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.