ICG 001

Pricing Availability Delivery Time Qty
Cat.No. 4505 - ICG 001 | C33H32N4O4 | CAS No. 847591-62-2
Description: Inhibits TCF/β-catenin-mediated transcription
Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature
Pathways

Biological Activity

Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

Technical Data

M. Wt 548.63
Formula C33H32N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 847591-62-2
PubChem ID 11238147
InChI Key HQWTUOLCGKIECB-XZWHSSHBSA-N
Smiles O=C1CCN(C(NCC5=CC=CC=C5)=O)[C@]2([H])N1[C@@H](CC6=CC=C(O)C=C6)C(N(CC3=C(C=CC=C4)C4=CC=C3)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.86 100
ethanol 27.43 50

Preparing Stock Solutions

The following data is based on the product molecular weight 548.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.82 mL 9.11 mL 18.23 mL
5 mM 0.36 mL 1.82 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.82 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Emami et al (2004) A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc.Natl.Acad.Sci.USA 101 12682 PMID: 15314234

De Sousa et al (2011) Targeting wnt signaling in colon cancer stem cells. Clin.Cancer Res. 17 647 PMID: 21159886

Zhou et al (2012) Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-respo J.Biol.Chem. 287 7026 PMID: 22241478


If you know of a relevant reference for ICG 001, please let us know.

View Related Products by Target

Keywords: ICG001 inhibits inhibitors TCF t cell factors b-catenin beta-catenin β-catenin signaling signalling selectively Beta-catenin

3 Citations for ICG 001

Citations are publications that use Tocris products. Selected citations for ICG 001 include:

Long et al (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. J Clin Invest 7 10354 PMID: 26838601

Boulter et al (2015) WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. PLoS One 125 1269 PMID: 25689248

Corbett et al (2015) Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells. J Immunol 10 e0142794 PMID: 26566235


Do you know of a great paper that uses ICG 001 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for ICG 001

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.

Protocols

TODO: Add Protocols