ICG 001

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Description: Inhibits TCF/β-catenin-mediated transcription
Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (12)
Reviews (1)
Literature (1)
Pathways (1)

Biological Activity for ICG 001

ICG 001 is an inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

Technical Data for ICG 001

M. Wt 548.63
Formula C33H32N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 780757-88-2
PubChem ID 11238147
InChI Key HQWTUOLCGKIECB-XZWHSSHBSA-N
Smiles O=C1CCN(C(NCC5=CC=CC=C5)=O)[C@]2([H])N1[C@@H](CC6=CC=C(O)C=C6)C(N(CC3=C(C=CC=C4)C4=CC=C3)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ICG 001

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.86 100
ethanol 27.43 50

Preparing Stock Solutions for ICG 001

The following data is based on the product molecular weight 548.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.82 mL 9.11 mL 18.23 mL
5 mM 0.36 mL 1.82 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.82 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets for ICG 001

Certificate of Analysis / Product Datasheet
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References for ICG 001

References are publications that support the biological activity of the product.

Emami et al (2004) A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc.Natl.Acad.Sci.USA 101 12682 PMID: 15314234

De Sousa et al (2011) Targeting wnt signaling in colon cancer stem cells. Clin.Cancer Res. 17 647 PMID: 21159886

Zhou et al (2012) Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-respo J.Biol.Chem. 287 7026 PMID: 22241478


If you know of a relevant reference for ICG 001, please let us know.

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Keywords: ICG 001, ICG 001 supplier, ICG001, inhibits, inhibitors, TCF, t, cell, factors, b-catenin, beta-catenin, β-catenin, signaling, signalling, selectively, 847591-62-2, Beta-catenin, 4505, Tocris Bioscience

12 Citations for ICG 001

Citations are publications that use Tocris products. Selected citations for ICG 001 include:

Gravesen (2018) Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications. PLoS One 13 e0201936 PMID: 30075015

Nishiya et al (2014) A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol 21 530 PMID: 24684907

Kling et al (2018) Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling. Front Immunol 9 483 PMID: 29616022

Long et al (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. J Clin Invest 7 10354 PMID: 26838601


Do you know of a great paper that uses ICG 001 from Tocris? Please let us know.

Reviews for ICG 001

Average Rating: 5 (Based on 1 Review.)

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Good product..
By Anonymous on 07/07/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: BLaER1 DRP1 KO cell lines

BLaER1 DRP1 KO cell lines C12 and F11 and a corresponding wt-control cell line were treated with 10 µM ICG-001 or vehicle control for 2.5 h.

PMID: 29290987
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for ICG 001

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.