Inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3 beta /AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 456.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.19 mL||10.95 mL||21.9 mL|
|5 mM||0.44 mL||2.19 mL||4.38 mL|
|10 mM||0.22 mL||1.1 mL||2.19 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Waaler et al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197 PMID: 21199802
If you know of a relevant reference for JW 74, please let us know.
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Keywords: JW 74, JW 74 supplier, JW74, canonical, Wnt, signaling, pathway, inhibitors, inhibits, cancer, β-catenin, AXIN2, Beta-catenin, Other, Signaling, 5653, Tocris Bioscience
1 Citation for JW 74
Citations are publications that use Tocris products. Selected citations for JW 74 include:
Rothberg (2018) Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. Cell Discov 4 21 PMID: 29736258
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