Calphostin C

Pricing Availability   Qty
Description: Potent, selective and photo-dependent PKC inhibitor
Alternative Names: UCN 1028C, PKF 115584
Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Purity: ≥95% (HPLC)
Citations (7)
Literature (3)

Biological Activity for Calphostin C

Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.

Technical Data for Calphostin C

M. Wt 790.76
Formula C44H38O14
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 121263-19-2
PubChem ID 6604893
Smiles O=C1C(OC)=C(C[C@@H](C)OC(C2=CC=CC=C2)=O)C3=C4C5=C(C(OC)=CC(O)=C5C(C(OC)=C4C[C@@H](C)OC(OC6=CC=C(O)C=C6)=O)=O)C7=C(OC)C=C(O)C1=C73

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Calphostin C

Solubility Soluble in DMSO and in ethanol

Product Datasheets for Calphostin C

Certificate of Analysis / Product Datasheet
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References for Calphostin C

References are publications that support the biological activity of the product.

Pollack and Kawecki (1997) The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 31 255 PMID: 9049854

Au et al (2006) Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 85 92 PMID: 16829117

Kobayashi et al (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm. 159 548

Matsuzaki and Darcha (2013) In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One 8 e61690 PMID: 23626717

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Keywords: Calphostin C, Calphostin C supplier, Potent, selective, photo-dependent, PKC, inhibitors, inhibits, Protein, Kinases, C, CalphostinC, UCN1028C, PKF115-584, stem, cells, UCN, 1028C, PKF, 115584, Kinase, Beta-catenin, 1626, Tocris Bioscience

7 Citations for Calphostin C

Citations are publications that use Tocris products. Selected citations for Calphostin C include:

Liang et al (2014) δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Br J Pharmacol 171 5417 PMID: 25052197

Kou et al (2019) Vascular endothelial growth factor increases the function of calcium-impermeable AMPA receptor GluA2 subunit in astrocytes via activation of protein kinase C signaling pathway. Glia 67 1344 PMID: 30883902

Most et al (2013) S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circ Res 112 66 PMID: 23048072

Kaul and Maltese (2009) Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. Neoplasia 11 823 PMID: 19724676

Do you know of a great paper that uses Calphostin C from Tocris? Please let us know.

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Literature in this Area

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